Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 68832..69358 Replicon plasmid unnamed1
Accession NZ_CP118553
Organism Enterobacter hormaechei strain 2020CK-00206

Toxin (Protein)


Gene name relE Uniprot ID A0A7R6HXL1
Locus tag PWP98_RS23945 Protein ID WP_015572079.1
Coordinates 69071..69358 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag PWP98_RS23940 Protein ID WP_000534858.1
Coordinates 68832..69071 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PWP98_RS23910 (PWP98_23910) 63905..64840 - 936 WP_004118100.1 GlxA family transcriptional regulator -
PWP98_RS23915 (PWP98_23915) 64851..66053 - 1203 WP_015572077.1 MFS transporter -
PWP98_RS23920 (PWP98_23920) 66093..66854 - 762 WP_004118132.1 SDR family NAD(P)-dependent oxidoreductase -
PWP98_RS23925 (PWP98_23925) 66884..67699 - 816 WP_032670836.1 SDR family oxidoreductase -
PWP98_RS23930 (PWP98_23930) 68163..68483 + 321 WP_004197483.1 hypothetical protein -
PWP98_RS23935 (PWP98_23935) 68705..68807 - 103 Protein_74 hypothetical protein -
PWP98_RS23940 (PWP98_23940) 68832..69071 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
PWP98_RS23945 (PWP98_23945) 69071..69358 + 288 WP_015572079.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PWP98_RS23950 (PWP98_23950) 69430..69588 + 159 WP_013087178.1 type I toxin-antitoxin system Hok family toxin -
PWP98_RS23955 (PWP98_23955) 70457..70831 + 375 WP_049127080.1 hypothetical protein -
PWP98_RS23960 (PWP98_23960) 70828..71175 + 348 WP_045325353.1 hypothetical protein -
PWP98_RS23965 (PWP98_23965) 71879..72172 + 294 WP_032670838.1 hypothetical protein -
PWP98_RS23970 (PWP98_23970) 72189..73010 + 822 WP_015572081.1 DUF932 domain-containing protein -
PWP98_RS23975 (PWP98_23975) 73039..73578 - 540 WP_032664846.1 lytic transglycosylase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..175470 175470


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11209.09 Da        Isoelectric Point: 10.0714

>T273230 WP_015572079.1 NZ_CP118553:69071-69358 [Enterobacter hormaechei]
MAYFLDFDERALKEWRKLGSTVREQLKNKLAEVLESPRIDANKLRGMHDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT273230 WP_000534858.1 NZ_CP118553:68832-69071 [Enterobacter hormaechei]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References