Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4829975..4830591 Replicon chromosome
Accession NZ_CP118552
Organism Enterobacter hormaechei strain 2020CK-00206

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PWP98_RS23175 Protein ID WP_017382676.1
Coordinates 4829975..4830346 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6G4MTK3
Locus tag PWP98_RS23180 Protein ID WP_015569912.1
Coordinates 4830349..4830591 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PWP98_RS23160 (PWP98_23160) 4827475..4828377 + 903 WP_014072386.1 formate dehydrogenase subunit beta -
PWP98_RS23165 (PWP98_23165) 4828374..4829009 + 636 WP_015569914.1 formate dehydrogenase cytochrome b556 subunit -
PWP98_RS23170 (PWP98_23170) 4829006..4829935 + 930 WP_003861956.1 formate dehydrogenase accessory protein FdhE -
PWP98_RS23175 (PWP98_23175) 4829975..4830346 - 372 WP_017382676.1 type II toxin-antitoxin system VapC family toxin Toxin
PWP98_RS23180 (PWP98_23180) 4830349..4830591 - 243 WP_015569912.1 ribbon-helix-helix domain-containing protein Antitoxin
PWP98_RS23185 (PWP98_23185) 4830790..4831782 + 993 WP_080347228.1 alpha/beta hydrolase -
PWP98_RS23190 (PWP98_23190) 4831719..4832660 - 942 WP_015569910.1 fatty acid biosynthesis protein FabY -
PWP98_RS23195 (PWP98_23195) 4832705..4833142 - 438 WP_015569909.1 D-aminoacyl-tRNA deacylase -
PWP98_RS23200 (PWP98_23200) 4833139..4834020 - 882 WP_003861949.1 virulence factor BrkB family protein -
PWP98_RS23205 (PWP98_23205) 4834014..4834613 - 600 WP_017694048.1 glucose-1-phosphatase -
PWP98_RS23210 (PWP98_23210) 4834732..4835532 - 801 WP_047746063.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13737.88 Da        Isoelectric Point: 6.4882

>T273229 WP_017382676.1 NZ_CP118552:c4830346-4829975 [Enterobacter hormaechei]
MEHMAVFDTNILIDLFNNRIEAADAIEHTASHRAISLITWMEVMVGARRHGHEAKTAAVMGAFEIIDVSRDIAERSVLLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFAGIDEVLTPYQV

Download         Length: 372 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9440.72 Da        Isoelectric Point: 4.4076

>AT273229 WP_015569912.1 NZ_CP118552:c4830591-4830349 [Enterobacter hormaechei]
MSVLAELDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRNALGLWGDRKEDGLEYERKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6G4MTK3

References