Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 579314..579934 Replicon chromosome
Accession NZ_CP118552
Organism Enterobacter hormaechei strain 2020CK-00206

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag PWP98_RS02745 Protein ID WP_015571250.1
Coordinates 579314..579532 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag PWP98_RS02750 Protein ID WP_006809850.1
Coordinates 579560..579934 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PWP98_RS02715 (PWP98_02715) 575326..575586 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
PWP98_RS02720 (PWP98_02720) 575589..575729 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
PWP98_RS02725 (PWP98_02725) 575726..576436 - 711 WP_017383207.1 GNAT family protein -
PWP98_RS02730 (PWP98_02730) 576538..577998 + 1461 WP_058685706.1 PLP-dependent aminotransferase family protein -
PWP98_RS02735 (PWP98_02735) 577970..578437 - 468 WP_023296041.1 YlaC family protein -
PWP98_RS02740 (PWP98_02740) 578554..579105 - 552 WP_047746134.1 maltose O-acetyltransferase -
PWP98_RS02745 (PWP98_02745) 579314..579532 - 219 WP_015571250.1 HHA domain-containing protein Toxin
PWP98_RS02750 (PWP98_02750) 579560..579934 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
PWP98_RS02755 (PWP98_02755) 580445..583591 - 3147 WP_015571248.1 multidrug efflux RND transporter permease subunit AcrB -
PWP98_RS02760 (PWP98_02760) 583614..584807 - 1194 WP_017694395.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T273220 WP_015571250.1 NZ_CP118552:c579532-579314 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT273220 WP_006809850.1 NZ_CP118552:c579934-579560 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References