Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 832266..832914 Replicon chromosome
Accession NZ_CP118537
Organism Salmonella enterica subsp. enterica serovar Typhi strain S3

Toxin (Protein)


Gene name cptA Uniprot ID A0A715BCB4
Locus tag O1A30_RS04085 Protein ID WP_000244762.1
Coordinates 832513..832914 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag O1A30_RS04080 Protein ID WP_000351186.1
Coordinates 832266..832532 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O1A30_RS04060 (O1A30_04060) 828194..829627 - 1434 WP_001230148.1 6-phospho-beta-glucosidase BglA -
O1A30_RS04065 (O1A30_04065) 829786..830097 + 312 WP_001182971.1 N(4)-acetylcytidine aminohydrolase -
O1A30_RS04070 (O1A30_04070) 830261..830920 + 660 WP_000250289.1 hemolysin III family protein -
O1A30_RS04075 (O1A30_04075) 831036..832016 - 981 WP_000874170.1 tRNA-modifying protein YgfZ -
O1A30_RS04080 (O1A30_04080) 832266..832532 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
O1A30_RS04085 (O1A30_04085) 832513..832914 + 402 WP_000244762.1 protein YgfX Toxin
O1A30_RS04090 (O1A30_04090) 832979..833500 - 522 WP_001055885.1 flavodoxin FldB -
O1A30_RS04095 (O1A30_04095) 833613..834509 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
O1A30_RS04100 (O1A30_04100) 834533..835246 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
O1A30_RS04105 (O1A30_04105) 835252..836985 + 1734 WP_000813396.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15773.75 Da        Isoelectric Point: 10.7537

>T273165 WP_000244762.1 NZ_CP118537:832513-832914 [Salmonella enterica subsp. enterica serovar Typhi]
VVLWQSDLRVSWRAQWISLLLHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPI

Download         Length: 402 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT273165 WP_000351186.1 NZ_CP118537:832266-832532 [Salmonella enterica subsp. enterica serovar Typhi]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A715BCB4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References