Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2288990..2289822 Replicon chromosome
Accession NC_017633
Organism Escherichia coli ETEC H10407

Toxin (Protein)


Gene name yeeV Uniprot ID E3PBK9
Locus tag ETEC_RS11605 Protein ID WP_000854755.1
Coordinates 2289448..2289822 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag ETEC_RS11600 Protein ID WP_024185641.1
Coordinates 2288990..2289358 (+) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ETEC_RS11565 2286108..2286266 + 159 WP_001323397.1 DUF905 family protein -
ETEC_RS11570 2286421..2287239 + 819 WP_001234725.1 DUF945 domain-containing protein -
ETEC_RS11575 2287239..2287484 + 246 WP_000680585.1 hypothetical protein -
ETEC_RS11580 2287578..2288051 + 474 WP_024185640.1 antirestriction protein -
ETEC_RS11585 2288067..2288543 + 477 WP_001186774.1 RadC family protein -
ETEC_RS11590 2288606..2288827 + 222 WP_000692345.1 DUF987 domain-containing protein -
ETEC_RS11600 2288990..2289358 + 369 WP_024185641.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
ETEC_RS11605 2289448..2289822 + 375 WP_000854755.1 TA system toxin CbtA family protein Toxin
ETEC_RS11610 2289819..2290025 + 207 WP_000976829.1 hypothetical protein -
ETEC_RS30655 2290038..2290151 + 114 WP_001161660.1 DUF957 domain-containing protein -
ETEC_RS27205 2290272..2291636 - 1365 Protein_2201 IS66-like element ISEc23 family transposase -
ETEC_RS11635 2291686..2292899 + 1214 WP_139371347.1 IS3 family transposase -
ETEC_RS11640 2292944..2293198 - 255 Protein_2203 IS66 family transposase -
ETEC_RS11645 2293229..2293579 - 351 WP_000624722.1 IS66 family insertion sequence element accessory protein TnpB -
ETEC_RS11650 2293576..2294001 - 426 WP_000422741.1 IS66 family insertion sequence hypothetical protein -
ETEC_RS30660 2294089..2294229 + 141 Protein_2206 IS3 family transposase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 125 a.a.        Molecular weight: 13907.84 Da        Isoelectric Point: 7.7760

>T27316 WP_000854755.1 NC_017633:2289448-2289822 [Escherichia coli ETEC H10407]
MKTLPDTHVREASSCPSPVTTWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T27316 NC_017633:2289448-2289822 [Escherichia coli ETEC H10407]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCACCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13599.37 Da        Isoelectric Point: 6.3173

>AT27316 WP_024185641.1 NC_017633:2288990-2289358 [Escherichia coli ETEC H10407]
VSDTLSGTTHPDDNDDHPWWRLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT27316 NC_017633:2288990-2289358 [Escherichia coli ETEC H10407]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGAGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB E3PBK9


Antitoxin

Source ID Structure

References