Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 3348995..3350717 Replicon chromosome
Accession NZ_CP118227
Organism Proteus mirabilis strain CY32

Toxin (Protein)


Gene name mosT Uniprot ID D0FZT9
Locus tag PU712_RS15750 Protein ID WP_000356587.1
Coordinates 3348995..3349933 (-) Length 313 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A0A1U9VYW4
Locus tag PU712_RS15755 Protein ID WP_000095578.1
Coordinates 3349926..3350717 (-) Length 264 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PU712_RS15730 (PU712_15730) 3344936..3345448 - 513 WP_024008829.1 S26 family signal peptidase -
PU712_RS15735 (PU712_15735) 3345432..3345779 - 348 WP_024008830.1 hypothetical protein -
PU712_RS15740 (PU712_15740) 3345772..3348171 - 2400 WP_024008831.1 type IV secretion system protein TraC -
PU712_RS15745 (PU712_15745) 3348171..3348863 - 693 WP_024008832.1 DsbC family protein -
PU712_RS15750 (PU712_15750) 3348995..3349933 - 939 WP_000356587.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
PU712_RS15755 (PU712_15755) 3349926..3350717 - 792 WP_000095578.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
PU712_RS15760 (PU712_15760) 3350938..3351324 - 387 WP_000180225.1 TraA family conjugative transfer protein -
PU712_RS15765 (PU712_15765) 3351321..3351893 - 573 WP_024008834.1 type IV conjugative transfer system lipoprotein TraV -
PU712_RS15770 (PU712_15770) 3351968..3353257 - 1290 WP_049195464.1 TraB/VirB10 family protein -
PU712_RS15775 (PU712_15775) 3353260..3354156 - 897 WP_032194332.1 type-F conjugative transfer system secretin TraK -
PU712_RS15780 (PU712_15780) 3354140..3354766 - 627 WP_000667167.1 TraE/TraK family type IV conjugative transfer system protein -
PU712_RS15785 (PU712_15785) 3354763..3355044 - 282 WP_000433891.1 type IV conjugative transfer system protein TraL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element tet(J) / blaCMY-2 - 3249958..3444614 194656


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(99-250)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 35548.82 Da        Isoelectric Point: 4.9081

>T272957 WP_000356587.1 NZ_CP118227:c3349933-3348995 [Proteus mirabilis]
MDKDSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALINVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSPVATIKIEVSPVARGTLHSAEIMPVQESVEDEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGISREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLIELQK
HFTERDHAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE

Download         Length: 939 bp

Antitoxin


Download         Length: 264 a.a.        Molecular weight: 30095.47 Da        Isoelectric Point: 9.5097

>AT272957 WP_000095578.1 NZ_CP118227:c3350717-3349926 [Proteus mirabilis]
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLSSGVYYRPNAQGDIKPTWVDAIQALDVQLGVPVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRVDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG

Download         Length: 792 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1U9VZ44

Antitoxin

Source ID Structure
AlphaFold DB A0A1U9VYW4

References