Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 769603..770297 Replicon chromosome
Accession NZ_CP118155
Organism Pseudomonas chlororaphis strain ATCC 17411

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PUP78_RS03480 Protein ID WP_053268076.1
Coordinates 769603..769899 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PUP78_RS03485 Protein ID WP_124323351.1
Coordinates 769896..770297 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUP78_RS03445 (PUP78_03445) 765140..765685 - 546 WP_025808153.1 membrane protein -
PUP78_RS03450 (PUP78_03450) 765682..765936 - 255 WP_007926835.1 acyl carrier protein -
PUP78_RS03455 (PUP78_03455) 765946..766206 - 261 WP_025808152.1 phosphopantetheine-binding protein -
PUP78_RS03460 (PUP78_03460) 766181..766996 - 816 WP_124323349.1 lysophospholipid acyltransferase family protein -
PUP78_RS03465 (PUP78_03465) 766972..767703 - 732 WP_036998144.1 beta-ketoacyl synthase chain length factor -
PUP78_RS03470 (PUP78_03470) 768035..768805 + 771 WP_097305890.1 ParA family protein -
PUP78_RS03475 (PUP78_03475) 768931..769365 - 435 WP_124323350.1 thioredoxin TrxC -
PUP78_RS03480 (PUP78_03480) 769603..769899 + 297 WP_053268076.1 type II toxin-antitoxin system HigB family toxin Toxin
PUP78_RS03485 (PUP78_03485) 769896..770297 + 402 WP_124323351.1 transcriptional regulator Antitoxin
PUP78_RS03490 (PUP78_03490) 770302..771765 - 1464 WP_124323352.1 YdiU family protein -
PUP78_RS03495 (PUP78_03495) 771814..775161 - 3348 WP_124323353.1 mechanosensitive channel MscK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-90)

Antitoxin

Cro/C1-type helix-turn-helix domain

(80-132)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11588.41 Da        Isoelectric Point: 10.6515

>T272898 WP_053268076.1 NZ_CP118155:769603-769899 [Pseudomonas chlororaphis]
MHIITAKRIWEAKSRWPQSANALETWYRKVKSLNPADFAAIKAVFPATDKVGAFHVFDIGGNKLRIIAVVRYEVRRLYIR
HVLDHHEYDKGRWKEETR

Download         Length: 297 bp

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14925.01 Da        Isoelectric Point: 4.5517

>AT272898 WP_124323351.1 NZ_CP118155:769896-770297 [Pseudomonas chlororaphis]
MNVLVRQAAEHWHFVAPVLRKPKTEADYDALVVALDELLDLMGEDENHPVTSLVDIIGDWIEAYDEEHRPMPIASGVDVL
RSLMREHGLTQSDLPGVGAQSVVSEVLSGKRQLNLRQIRWLAERFGVSAEVFI

Download         Length: 402 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References