Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2685216..2685829 Replicon chromosome
Accession NZ_CP118152
Organism Pseudomonas chlororaphis strain ATCC 336631

Toxin (Protein)


Gene name hicA Uniprot ID A0A285EYZ4
Locus tag PUP64_RS12315 Protein ID WP_009041685.1
Coordinates 2685647..2685829 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A554PT90
Locus tag PUP64_RS12310 Protein ID WP_009046450.1
Coordinates 2685216..2685617 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUP64_RS12295 (PUP64_12295) 2680232..2681557 - 1326 WP_081362981.1 LLM class flavin-dependent oxidoreductase -
PUP64_RS12300 (PUP64_12300) 2681604..2683862 - 2259 WP_081362982.1 TonB-dependent receptor -
PUP64_RS12305 (PUP64_12305) 2684070..2685116 + 1047 WP_081362983.1 LacI family DNA-binding transcriptional regulator -
PUP64_RS12310 (PUP64_12310) 2685216..2685617 - 402 WP_009046450.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PUP64_RS12315 (PUP64_12315) 2685647..2685829 - 183 WP_009041685.1 type II toxin-antitoxin system HicA family toxin Toxin
PUP64_RS12320 (PUP64_12320) 2685954..2686844 - 891 WP_081362984.1 LysR family transcriptional regulator -
PUP64_RS12325 (PUP64_12325) 2686983..2687723 + 741 WP_081362985.1 SDR family oxidoreductase -
PUP64_RS12330 (PUP64_12330) 2687757..2688266 + 510 WP_081362986.1 DUF1097 domain-containing protein -
PUP64_RS12335 (PUP64_12335) 2688295..2689191 + 897 WP_081362987.1 SDR family oxidoreductase -
PUP64_RS12340 (PUP64_12340) 2689265..2689753 + 489 WP_028683850.1 DoxX family protein -
PUP64_RS12345 (PUP64_12345) 2689806..2690063 + 258 WP_009046444.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6933.08 Da        Isoelectric Point: 10.4588

>T272882 WP_009041685.1 NZ_CP118152:c2685829-2685647 [Pseudomonas chlororaphis]
MRSRELIRMIEEDGWYLIAVKGSHHQYKHLHKPGRVTIPHPDADLPRGTIHSILKQAGLK

Download         Length: 183 bp

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14596.44 Da        Isoelectric Point: 4.9133

>AT272882 WP_009046450.1 NZ_CP118152:c2685617-2685216 [Pseudomonas chlororaphis]
MKFPVVLHKDADSGYGVIVPDVPGCFSAGHTAAQAFENVKEALSLHYEGLVADGEPLPQVHEVDVHIDNPDYAGGVWGVI
EFDITPYFGKAVRFNATLPEQLLERIDQTVKRDQRYRSRSGFLAAAALRELSA

Download         Length: 402 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A285EYZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A554PT90

References