Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 698318..698888 Replicon chromosome
Accession NZ_CP118152
Organism Pseudomonas chlororaphis strain ATCC 336631

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag PUP64_RS03190 Protein ID WP_081363241.1
Coordinates 698318..698596 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A3G7ICX6
Locus tag PUP64_RS03195 Protein ID WP_038580367.1
Coordinates 698598..698888 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUP64_RS03175 (PUP64_03175) 693948..695192 - 1245 WP_029527362.1 M20/M25/M40 family metallo-hydrolase -
PUP64_RS03180 (PUP64_03180) 695286..696410 - 1125 WP_081362127.1 diguanylate cyclase -
PUP64_RS03185 (PUP64_03185) 696675..698069 + 1395 WP_081362128.1 VOC family protein -
PUP64_RS03190 (PUP64_03190) 698318..698596 + 279 WP_081363241.1 addiction module antitoxin RelB Toxin
PUP64_RS03195 (PUP64_03195) 698598..698888 + 291 WP_038580367.1 putative addiction module antidote protein Antitoxin
PUP64_RS03200 (PUP64_03200) 699288..699875 - 588 WP_081362129.1 hypothetical protein -
PUP64_RS03205 (PUP64_03205) 699989..701065 - 1077 WP_081362130.1 lipocalin-like domain-containing protein -
PUP64_RS03210 (PUP64_03210) 701055..703571 - 2517 WP_232000815.1 FtsX-like permease family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-92)

Antitoxin

Uncharacterized protein HI1420

(8-94)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10061.59 Da        Isoelectric Point: 11.0291

>T272879 WP_081363241.1 NZ_CP118152:698318-698596 [Pseudomonas chlororaphis]
MQTTVFAQWHTTLRDLRARIAIARRIERASAGNLGDVKNLGGGLSEMRVNTGAGYRLYFTVRGNPLIVLLLGGDKSSQPA
DICQARSLAKEF

Download         Length: 279 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10239.78 Da        Isoelectric Point: 8.0096

>AT272879 WP_038580367.1 NZ_CP118152:698598-698888 [Pseudomonas chlororaphis]
MSDTLVPFDIAALLDSDQAISEYLSQVLADGDTDELIRALGHVARARGMTQIAKTTGQGRASLYKAFAPGAKPRFDTVVK
VMRALGLQLCTTVSRG

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3G7ICX6

References