Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 546964..547577 Replicon chromosome
Accession NZ_CP118141
Organism Pseudomonas chlororaphis strain ATCC 17814

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag PUP70_RS02460 Protein ID WP_053259259.1
Coordinates 546964..547146 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2N8BII0
Locus tag PUP70_RS02465 Protein ID WP_009041686.1
Coordinates 547176..547577 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUP70_RS02435 (PUP70_02435) 543104..543361 - 258 WP_053259255.1 hypothetical protein -
PUP70_RS02440 (PUP70_02440) 543601..544497 - 897 WP_007925288.1 SDR family oxidoreductase -
PUP70_RS02445 (PUP70_02445) 544527..545036 - 510 WP_053259256.1 DUF1097 domain-containing protein -
PUP70_RS02450 (PUP70_02450) 545070..545810 - 741 WP_053259257.1 SDR family oxidoreductase -
PUP70_RS02455 (PUP70_02455) 545949..546839 + 891 WP_053259258.1 LysR family transcriptional regulator -
PUP70_RS02460 (PUP70_02460) 546964..547146 + 183 WP_053259259.1 type II toxin-antitoxin system HicA family toxin Toxin
PUP70_RS02465 (PUP70_02465) 547176..547577 + 402 WP_009041686.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PUP70_RS02470 (PUP70_02470) 547666..548712 - 1047 WP_053259260.1 LacI family DNA-binding transcriptional regulator -
PUP70_RS02475 (PUP70_02475) 548919..551177 + 2259 WP_053259261.1 TonB-dependent receptor -
PUP70_RS02480 (PUP70_02480) 551224..552549 + 1326 WP_009041689.1 LLM class flavin-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6959.11 Da        Isoelectric Point: 10.2817

>T272807 WP_053259259.1 NZ_CP118141:546964-547146 [Pseudomonas chlororaphis]
MRSRELIRMIEEDGWYLIAVKGSHHQYKYLHKPGRVTIPHPDADLPRGTIHSILKQAGLK

Download         Length: 183 bp

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14629.48 Da        Isoelectric Point: 4.7569

>AT272807 WP_009041686.1 NZ_CP118141:547176-547577 [Pseudomonas chlororaphis]
MKFPVVLHKDADSGYGVIVPDVPGCFSAGHTAAEAFENVKEALSLHYEGLVADGEPLPQVHEVDVHIDNPDYAGGVWGMI
EFDITPYFGKAVRFNATLPEQLLERIDQTVKRDQRYRSRSGFLAAAALRELSA

Download         Length: 402 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2N8BII0

References