Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 7053169..7053788 Replicon chromosome
Accession NZ_CP118138
Organism Pseudomonas chlororaphis strain DSM 295782

Toxin (Protein)


Gene name hicA Uniprot ID A0A285IZB4
Locus tag PUP77_RS31910 Protein ID WP_009043086.1
Coordinates 7053169..7053351 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PUP77_RS31915 Protein ID WP_053278311.1
Coordinates 7053387..7053788 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUP77_RS31890 (PUP77_31890) 7050017..7050745 - 729 WP_274320654.1 hypothetical protein -
PUP77_RS31895 (PUP77_31895) 7051159..7051440 + 282 WP_274320655.1 hypothetical protein -
PUP77_RS31900 (PUP77_31900) 7051805..7052161 + 357 WP_103330827.1 hypothetical protein -
PUP77_RS31905 (PUP77_31905) 7052583..7052864 + 282 WP_274320656.1 hypothetical protein -
PUP77_RS31910 (PUP77_31910) 7053169..7053351 + 183 WP_009043086.1 type II toxin-antitoxin system HicA family toxin Toxin
PUP77_RS31915 (PUP77_31915) 7053387..7053788 + 402 WP_053278311.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PUP77_RS31920 (PUP77_31920) 7054322..7055575 - 1254 WP_274320657.1 OprD family porin -
PUP77_RS31925 (PUP77_31925) 7055707..7057182 - 1476 WP_274320658.1 aldehyde dehydrogenase family protein -
PUP77_RS31930 (PUP77_31930) 7057258..7058196 - 939 WP_053278731.1 2-dehydropantoate 2-reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6800.02 Da        Isoelectric Point: 11.0738

>T272793 WP_009043086.1 NZ_CP118138:7053169-7053351 [Pseudomonas chlororaphis]
VQSRQLIKELEAAGWVLERVTGSHHLFKHPYRPETVPVPHPKKDLPRGTVRAIKKLAGLI

Download         Length: 183 bp

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14591.59 Da        Isoelectric Point: 4.6017

>AT272793 WP_053278311.1 NZ_CP118138:7053387-7053788 [Pseudomonas chlororaphis]
VQYPICIEWGDEHTATGIQIPDIPGAVTAGDTFEAAYSAAIEIAHVMLEELAREGQAIPLPSPTGIHRANPDFEGMGWGM
LDIDITPYLGKTEKVNVTLPGYVIQRIDRFVREHNIKSRSSFLADAAMEKLGR

Download         Length: 402 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A285IZB4

Antitoxin

Source ID Structure

References