Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1459563..1460217 Replicon chromosome
Accession NZ_CP118014
Organism Escherichia coli strain B-766

Toxin (Protein)


Gene name cptA Uniprot ID F4NJ21
Locus tag PT280_RS07150 Protein ID WP_000244772.1
Coordinates 1459810..1460217 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag PT280_RS07145 Protein ID WP_000354046.1
Coordinates 1459563..1459829 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT280_RS07120 (1454851) 1454851..1455594 + 744 WP_000951964.1 SDR family oxidoreductase -
PT280_RS07125 (1455651) 1455651..1457084 - 1434 WP_001307385.1 6-phospho-beta-glucosidase BglA -
PT280_RS07130 (1457129) 1457129..1457440 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
PT280_RS07135 (1457604) 1457604..1458263 + 660 WP_000250274.1 hemolysin III family protein -
PT280_RS07140 (1458340) 1458340..1459320 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
PT280_RS07145 (1459563) 1459563..1459829 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
PT280_RS07150 (1459810) 1459810..1460217 + 408 WP_000244772.1 protein YgfX Toxin
PT280_RS07155 (1460257) 1460257..1460778 - 522 WP_001055874.1 flavodoxin FldB -
PT280_RS07160 (1460890) 1460890..1461786 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
PT280_RS07165 (1461811) 1461811..1462521 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PT280_RS07170 (1462527) 1462527..1464260 + 1734 WP_000813215.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16048.02 Da        Isoelectric Point: 11.2511

>T272675 WP_000244772.1 NZ_CP118014:1459810-1460217 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT272675 WP_000354046.1 NZ_CP118014:1459563-1459829 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYB4

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References