Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 632123..632842 Replicon chromosome
Accession NZ_CP118014
Organism Escherichia coli strain B-766

Toxin (Protein)


Gene name yeeV Uniprot ID E0J373
Locus tag PT280_RS03095 Protein ID WP_001095907.1
Coordinates 632123..632443 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID E0J374
Locus tag PT280_RS03100 Protein ID WP_001192122.1
Coordinates 632477..632842 (-) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT280_RS03070 (627801) 627801..628094 - 294 WP_000805509.1 protein YicS -
PT280_RS03075 (628316) 628316..629134 + 819 WP_000779426.1 lipoprotein NlpA -
PT280_RS03080 (629138) 629138..630061 - 924 WP_000535960.1 carboxylate/amino acid/amine transporter -
PT280_RS03085 (630172) 630172..631356 - 1185 WP_001172876.1 sugar efflux transporter -
PT280_RS03090 (631753) 631753..631914 - 162 Protein_578 RhuM family protein -
PT280_RS03095 (632123) 632123..632443 - 321 WP_001095907.1 TA system toxin CbtA family protein Toxin
PT280_RS03100 (632477) 632477..632842 - 366 WP_001192122.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
PT280_RS03105 (632874) 632874..633095 - 222 WP_000691985.1 DUF987 family protein -
PT280_RS03110 (633104) 633104..633574 - 471 WP_000104319.1 DNA repair protein RadC -
PT280_RS03115 (633644) 633644..634465 - 822 WP_000197395.1 DUF932 domain-containing protein -
PT280_RS03120 (634537) 634537..635013 - 477 WP_001254693.1 hypothetical protein -
PT280_RS03125 (635230) 635230..636033 - 804 WP_001245321.1 hypothetical protein -
PT280_RS03130 (636265) 636265..637429 + 1165 Protein_586 IS3-like element IS3 family transposase -
PT280_RS03135 (637457) 637457..637750 - 294 WP_000945828.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(5-104)

Antitoxin

Antitoxin CbeA

(18-116)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12184.76 Da        Isoelectric Point: 5.5740

>T272671 WP_001095907.1 NZ_CP118014:c632443-632123 [Escherichia coli]
MNTPTVPATVTVSSRLSPVQVWQKLLTYILEHHYGLTINDTPFSNDTTIQEHIEAGVNLTDAVNFLVERFELVRIDQKGF
SWQDQEPWITSLDVRRAQFNLGLKRS

Download         Length: 321 bp

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13470.22 Da        Isoelectric Point: 6.8421

>AT272671 WP_001192122.1 NZ_CP118014:c632842-632477 [Escherichia coli]
MQSTTLSGTSAENVSCLQWGLKRNITPCFGARLVQEGNRLYFLADRAGFNGSFSDDEALRLDQAFPLMMKQLERMLTAGE
LDPRSQHCVTRHHNGLTCEADTLGSHGYVYIAIYPQSALTR

Download         Length: 366 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E0J373

Antitoxin

Source ID Structure
AlphaFold DB E0J374

References