Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3138159..3138852 Replicon chromosome
Accession NZ_CP117959
Organism Escherichia coli strain B-2207

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag PT284_RS16010 Protein ID WP_000415584.1
Coordinates 3138556..3138852 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag PT284_RS16005 Protein ID WP_000650107.1
Coordinates 3138159..3138554 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT284_RS15995 (3134023) 3134023..3136281 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
PT284_RS16000 (3136419) 3136419..3138026 - 1608 WP_021561146.1 ABC transporter substrate-binding protein -
PT284_RS16005 (3138159) 3138159..3138554 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
PT284_RS16010 (3138556) 3138556..3138852 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
PT284_RS16015 (3139057) 3139057..3139539 - 483 WP_000183505.1 GyrI-like domain-containing protein -
PT284_RS16020 (3139592) 3139592..3139984 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
PT284_RS16025 (3140136) 3140136..3140795 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
PT284_RS16030 (3140792) 3140792..3142141 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
PT284_RS16035 (3142187) 3142187..3142519 - 333 WP_000917684.1 DUF2645 family protein -
PT284_RS16040 (3142838) 3142838..3143419 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
PT284_RS16045 (3143450) 3143450..3143764 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T272506 WP_000415584.1 NZ_CP117959:c3138852-3138556 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT272506 WP_000650107.1 NZ_CP117959:c3138554-3138159 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References