Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 737835..738679 | Replicon | chromosome |
| Accession | NZ_CP117959 | ||
| Organism | Escherichia coli strain B-2207 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | B1LJY4 |
| Locus tag | PT284_RS04350 | Protein ID | WP_000854686.1 |
| Coordinates | 738296..738679 (+) | Length | 128 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A8E0J1S3 |
| Locus tag | PT284_RS04345 | Protein ID | WP_001285602.1 |
| Coordinates | 737835..738215 (+) | Length | 127 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PT284_RS04310 (734085) | 734085..734540 | + | 456 | WP_000581502.1 | IrmA family protein | - |
| PT284_RS04315 (734619) | 734619..734852 | + | 234 | WP_001119727.1 | DUF905 family protein | - |
| PT284_RS04320 (734953) | 734953..735769 | + | 817 | Protein_700 | DUF932 domain-containing protein | - |
| PT284_RS04325 (735861) | 735861..736346 | + | 486 | WP_000214307.1 | antirestriction protein | - |
| PT284_RS04330 (736362) | 736362..736838 | + | 477 | WP_021543704.1 | RadC family protein | - |
| PT284_RS04335 (736901) | 736901..737122 | + | 222 | WP_000692298.1 | DUF987 domain-containing protein | - |
| PT284_RS04340 (737141) | 737141..737824 | + | 684 | WP_000086768.1 | hypothetical protein | - |
| PT284_RS04345 (737835) | 737835..738215 | + | 381 | WP_001285602.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| PT284_RS04350 (738296) | 738296..738679 | + | 384 | WP_000854686.1 | TA system toxin CbtA family protein | Toxin |
| PT284_RS04355 (738676) | 738676..739164 | + | 489 | WP_001054233.1 | DUF5983 family protein | - |
| PT284_RS04360 (739181) | 739181..739378 | + | 198 | WP_000839256.1 | DUF957 domain-containing protein | - |
| PT284_RS04365 (739463) | 739463..740305 | + | 843 | WP_068879455.1 | DUF4942 domain-containing protein | - |
| PT284_RS04375 (740797) | 740797..741015 | - | 219 | WP_001040187.1 | translation initiation factor IF-1 | - |
| PT284_RS04380 (741300) | 741300..742004 | - | 705 | WP_001241678.1 | leucyl/phenylalanyl-tRNA--protein transferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 128 a.a. Molecular weight: 14272.28 Da Isoelectric Point: 6.8614
>T272493 WP_000854686.1 NZ_CP117959:738296-738679 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ
Download Length: 384 bp
Antitoxin
Download Length: 127 a.a. Molecular weight: 13938.69 Da Isoelectric Point: 5.0823
>AT272493 WP_001285602.1 NZ_CP117959:737835-738215 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE
Download Length: 381 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|