Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2295139..2295970 Replicon chromosome
Accession NC_017628
Organism Escherichia coli IHE3034

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag ECOK1_RS11710 Protein ID WP_000854814.1
Coordinates 2295596..2295970 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1PWQ3
Locus tag ECOK1_RS11705 Protein ID WP_001285586.1
Coordinates 2295139..2295507 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECOK1_RS11670 2290196..2291266 + 1071 WP_000102631.1 patatin-like phospholipase family protein -
ECOK1_RS11675 2291402..2292079 + 678 WP_001362823.1 hypothetical protein -
ECOK1_RS11680 2292095..2292505 + 411 WP_000846704.1 hypothetical protein -
ECOK1_RS11685 2292726..2293547 + 822 WP_001234570.1 DUF945 domain-containing protein -
ECOK1_RS11690 2293810..2294283 + 474 WP_000855074.1 antirestriction protein -
ECOK1_RS11695 2294299..2294775 + 477 WP_001351157.1 RadC family protein -
ECOK1_RS11700 2294844..2295065 + 222 WP_000692323.1 DUF987 domain-containing protein -
ECOK1_RS11705 2295139..2295507 + 369 WP_001285586.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
ECOK1_RS11710 2295596..2295970 + 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
ECOK1_RS11715 2295967..2296161 + 195 WP_000988601.1 hypothetical protein -
ECOK1_RS28420 2296174..2296287 + 114 WP_001161660.1 DUF957 domain-containing protein -
ECOK1_RS26725 2296576..2296722 - 147 Protein_2213 transposase domain-containing protein -
ECOK1_RS11725 2296776..2296958 + 183 WP_001016348.1 hypothetical protein -
ECOK1_RS11730 2297059..2297388 - 330 WP_000450409.1 DUF496 family protein -
ECOK1_RS11735 2297560..2298618 - 1059 WP_001200890.1 FUSC family protein -
ECOK1_RS11740 2298816..2299289 - 474 WP_001105376.1 DNA gyrase inhibitor SbmC -
ECOK1_RS11745 2299408..2300573 - 1166 Protein_2218 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T27246 WP_000854814.1 NC_017628:2295596-2295970 [Escherichia coli IHE3034]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T27246 NC_017628:2295596-2295970 [Escherichia coli IHE3034]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13563.41 Da        Isoelectric Point: 5.0468

>AT27246 WP_001285586.1 NC_017628:2295139-2295507 [Escherichia coli IHE3034]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT27246 NC_017628:2295139-2295507 [Escherichia coli IHE3034]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGTTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTCAGCCCCCGCTATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB S1PWQ3

References