Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 848468..849249 Replicon chromosome
Accession NZ_CP117852
Organism Salmonella enterica subsp. enterica serovar Mbandaka strain SM_F28R

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A3G3E5T9
Locus tag PTZ66_RS03995 Protein ID WP_000625911.1
Coordinates 848758..849249 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID V7IUD2
Locus tag PTZ66_RS03990 Protein ID WP_001271379.1
Coordinates 848468..848761 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTZ66_RS03955 (844770) 844770..845675 + 906 WP_001268200.1 YjiK family protein -
PTZ66_RS03960 (845969) 845969..846163 - 195 WP_223195369.1 hypothetical protein -
PTZ66_RS03965 (846211) 846211..846310 - 100 Protein_759 hypothetical protein -
PTZ66_RS03970 (846330) 846330..846497 + 168 WP_071527476.1 ATP-binding cassette domain-containing protein -
PTZ66_RS03975 (846504) 846504..846791 - 288 WP_072103482.1 transcriptional regulator RtsB -
PTZ66_RS03980 (846788) 846788..847663 - 876 WP_017441228.1 AraC family transcriptional regulator -
PTZ66_RS03985 (847929) 847929..848150 - 222 WP_001595143.1 hypothetical protein -
PTZ66_RS03990 (848468) 848468..848761 + 294 WP_001271379.1 DUF1778 domain-containing protein Antitoxin
PTZ66_RS03995 (848758) 848758..849249 + 492 WP_000625911.1 GNAT family N-acetyltransferase Toxin
PTZ66_RS04000 (849464) 849464..849712 + 249 Protein_766 IS481 family transposase -
PTZ66_RS04005 (849958) 849958..850215 - 258 WP_001112996.1 hypothetical protein -
PTZ66_RS04010 (850803) 850803..851093 + 291 WP_000773469.1 PapB/FocB family fimbrial expression transcriptional regulator -
PTZ66_RS04015 (851128) 851128..851667 + 540 WP_000721295.1 type 1 fimbrial protein -
PTZ66_RS04020 (851677) 851677..854115 + 2439 WP_017441226.1 F4 (K88) fimbrial usher FaeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - faeC / faeD / faeE / faeF / faeH / faeI 846788..861743 14955


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17663.44 Da        Isoelectric Point: 7.2655

>T272389 WP_000625911.1 NZ_CP117852:848758-849249 [Salmonella enterica subsp. enterica serovar Mbandaka]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFEPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10938.54 Da        Isoelectric Point: 9.8590

>AT272389 WP_001271379.1 NZ_CP117852:848468-848761 [Salmonella enterica subsp. enterica serovar Mbandaka]
MSAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G3E5T9

Antitoxin

Source ID Structure
AlphaFold DB V7IUD2

References