Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 21837..22495 Replicon plasmid unnamed2
Accession NZ_CP117763
Organism Acinetobacter baumannii strain 2022CK-00839

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PTC93_RS19500 Protein ID WP_000312250.1
Coordinates 21837..22196 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PTC93_RS19505 Protein ID WP_001096429.1
Coordinates 22196..22495 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC93_RS19470 (PTC93_19450) 17358..17672 - 315 WP_000708714.1 hypothetical protein -
PTC93_RS19475 (PTC93_19455) 18727..19485 - 759 WP_001053127.1 hypothetical protein -
PTC93_RS19480 (PTC93_19460) 19552..19935 - 384 WP_000654348.1 hypothetical protein -
PTC93_RS19485 (PTC93_19465) 20074..20772 - 699 WP_264208834.1 hypothetical protein -
PTC93_RS19490 (PTC93_19470) 20839..21021 - 183 WP_000373385.1 hypothetical protein -
PTC93_RS19495 (PTC93_19475) 21070..21636 - 567 WP_000710385.1 hypothetical protein -
PTC93_RS19500 (PTC93_19480) 21837..22196 + 360 WP_000312250.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PTC93_RS19505 (PTC93_19485) 22196..22495 + 300 WP_001096429.1 XRE family transcriptional regulator Antitoxin
PTC93_RS19510 (PTC93_19490) 23033..23569 - 537 WP_000731978.1 hypothetical protein -
PTC93_RS19515 (PTC93_19495) 23619..24173 - 555 WP_000790084.1 hypothetical protein -
PTC93_RS19520 (PTC93_19500) 24193..24411 - 219 WP_001043201.1 hypothetical protein -
PTC93_RS19525 (PTC93_19505) 24451..25080 - 630 WP_000701003.1 hypothetical protein -
PTC93_RS19530 (PTC93_19510) 25097..25276 - 180 WP_000387630.1 hypothetical protein -
PTC93_RS19535 (PTC93_19515) 25252..25824 - 573 WP_000443897.1 hypothetical protein -
PTC93_RS19540 (PTC93_19520) 25829..26086 - 258 WP_000834290.1 hypothetical protein -
PTC93_RS19545 (PTC93_19525) 26191..27471 - 1281 WP_001093570.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..66484 66484


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-109)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-88)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13751.62 Da        Isoelectric Point: 4.8212

>T272259 WP_000312250.1 NZ_CP117763:21837-22196 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Download         Length: 360 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11012.93 Da        Isoelectric Point: 10.4856

>AT272259 WP_001096429.1 NZ_CP117763:22196-22495 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References