Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 5149171..5150003 Replicon chromosome
Accession NC_017626
Organism Escherichia coli 042

Toxin (Protein)


Gene name yeeV Uniprot ID D3GX49
Locus tag EC042_RS25670 Protein ID WP_000854767.1
Coordinates 5149629..5150003 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7U9IW59
Locus tag EC042_RS25665 Protein ID WP_001360327.1
Coordinates 5149171..5149539 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC042_RS25625 5146286..5146444 + 159 WP_001323397.1 DUF905 family protein -
EC042_RS25635 5146599..5147417 + 819 WP_001234652.1 DUF945 domain-containing protein -
EC042_RS25645 5147759..5148232 + 474 WP_000855059.1 antirestriction protein -
EC042_RS25650 5148248..5148724 + 477 WP_001186774.1 RadC family protein -
EC042_RS25655 5148787..5149008 + 222 WP_000692286.1 DUF987 domain-containing protein -
EC042_RS25665 5149171..5149539 + 369 WP_001360327.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EC042_RS25670 5149629..5150003 + 375 WP_000854767.1 TA system toxin CbtA family protein Toxin
EC042_RS25685 5151465..5151827 + 363 Protein_4840 hypothetical protein -
EC042_RS25690 5151844..5152020 + 177 WP_000839290.1 DUF957 domain-containing protein -
EC042_RS30940 5152120..5152278 + 159 WP_001467148.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13945.89 Da        Isoelectric Point: 7.2909

>T27215 WP_000854767.1 NC_017626:5149629-5150003 [Escherichia coli 042]
MKTLPDTHVREVSCCPSPVTIWQTQLTRLLDQHYGLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SAGASSQLINSIDILRARRATGLMTRHNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T27215 NC_017626:5149629-5150003 [Escherichia coli 042]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACAGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCCA
CAACTACAGAACGGTGAACAATATCACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.34 Da        Isoelectric Point: 5.9598

>AT27215 WP_001360327.1 NC_017626:5149171-5149539 [Escherichia coli 042]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT27215 NC_017626:5149171-5149539 [Escherichia coli 042]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D3GX49

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9IW59

References