Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4833139..4833940 Replicon chromosome
Accession NC_017626
Organism Escherichia coli 042

Toxin (Protein)


Gene name yeeV Uniprot ID D3GU15
Locus tag EC042_RS24050 Protein ID WP_001094429.1
Coordinates 4833139..4833516 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID D3GU16
Locus tag EC042_RS24055 Protein ID WP_001285617.1
Coordinates 4833563..4833940 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC042_RS24030 4829506..4831044 - 1539 WP_001187199.1 lysine decarboxylation/transport transcriptional activator CadC -
EC042_RS24040 4831793..4832635 - 843 WP_001280493.1 DUF4942 domain-containing protein -
EC042_RS30385 4832720..4832917 - 198 WP_085949090.1 DUF957 domain-containing protein -
EC042_RS30390 4832945..4833142 - 198 Protein_4534 hypothetical protein -
EC042_RS24050 4833139..4833516 - 378 WP_001094429.1 TA system toxin CbtA family protein Toxin
EC042_RS24055 4833563..4833940 - 378 WP_001285617.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
EC042_RS24060 4834020..4834241 - 222 WP_000692350.1 DUF987 domain-containing protein -
EC042_RS24065 4834328..4834804 - 477 WP_001388380.1 RadC family protein -
EC042_RS24070 4834820..4835293 - 474 WP_000855083.1 antirestriction protein -
EC042_RS24075 4835595..4836413 - 819 WP_001234605.1 DUF945 domain-containing protein -
EC042_RS24080 4836513..4836746 - 234 WP_001119729.1 DUF905 family protein -
EC042_RS24085 4836825..4837280 - 456 WP_000581502.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13856.73 Da        Isoelectric Point: 6.8601

>T27214 WP_001094429.1 NC_017626:c4833516-4833139 [Escherichia coli 042]
MNTLPDTHVREASGCPSPITIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T27214 NC_017626:c4833516-4833139 [Escherichia coli 042]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCATCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13715.59 Da        Isoelectric Point: 6.6240

>AT27214 WP_001285617.1 NC_017626:c4833940-4833563 [Escherichia coli 042]
VSDTLPGTTPPDDNHDRLWWGLPCTVTPCFGARLVQKGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPATTV

Download         Length: 378 bp

>AT27214 NC_017626:c4833940-4833563 [Escherichia coli 042]
GTGTCAGACACACTCCCCGGGACAACGCCTCCCGACGACAATCACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGAAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCAGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCGCCCGCAACCACCGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XVU5

Antitoxin

Source ID Structure
AlphaFold DB D3GU16

References