Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3318201..3318855 Replicon chromosome
Accession NC_017626
Organism Escherichia coli 042

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag EC042_RS16605 Protein ID WP_000244777.1
Coordinates 3318201..3318608 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID D3GTR2
Locus tag EC042_RS16610 Protein ID WP_000354047.1
Coordinates 3318589..3318855 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC042_RS16585 3314158..3315891 - 1734 WP_000813224.1 single-stranded-DNA-specific exonuclease RecJ -
EC042_RS16590 3315897..3316607 - 711 WP_000715207.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EC042_RS16595 3316632..3317528 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
EC042_RS16600 3317640..3318161 + 522 WP_001055864.1 flavodoxin FldB -
EC042_RS16605 3318201..3318608 - 408 WP_000244777.1 toxin CptA Toxin
EC042_RS16610 3318589..3318855 - 267 WP_000354047.1 FAD assembly factor SdhE Antitoxin
EC042_RS16615 3319098..3320078 + 981 WP_000886074.1 tRNA-modifying protein YgfZ -
EC042_RS16620 3320155..3320814 - 660 WP_000250274.1 hemolysin III family protein -
EC042_RS16625 3320978..3321289 - 312 WP_001182951.1 N(4)-acetylcytidine aminohydrolase -
EC042_RS16630 3321334..3322767 + 1434 WP_001559758.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T27209 WP_000244777.1 NC_017626:c3318608-3318201 [Escherichia coli 042]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T27209 NC_017626:c3318608-3318201 [Escherichia coli 042]
GTGGTCCTGTGGCAATCTGATCTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATCCACGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10605.16 Da        Isoelectric Point: 4.9046

>AT27209 WP_000354047.1 NC_017626:c3318855-3318589 [Escherichia coli 042]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADEELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT27209 NC_017626:c3318855-3318589 [Escherichia coli 042]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCCGATC
TGTTTAACTGGCTGATGAACCACGGTAAACCGGCCGATGAAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
AlphaFold DB D3GTR2

References