Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2344347..2345178 Replicon chromosome
Accession NC_017626
Organism Escherichia coli 042

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag EC042_RS12055 Protein ID WP_000854814.1
Coordinates 2344804..2345178 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag EC042_RS12050 Protein ID WP_001285585.1
Coordinates 2344347..2344715 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC042_RS12020 2341251..2341706 + 456 WP_000581504.1 hypothetical protein -
EC042_RS12025 2341785..2342018 + 234 WP_001119729.1 DUF905 family protein -
EC042_RS12030 2342118..2342936 + 819 WP_001234629.1 DUF945 domain-containing protein -
EC042_RS12035 2343018..2343497 + 480 WP_000860087.1 antirestriction protein -
EC042_RS12040 2343513..2343989 + 477 WP_024165621.1 RadC family protein -
EC042_RS12045 2344052..2344273 + 222 WP_000692323.1 DUF987 domain-containing protein -
EC042_RS12050 2344347..2344715 + 369 WP_001285585.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
EC042_RS12055 2344804..2345178 + 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
EC042_RS12060 2345175..2345369 + 195 WP_000988600.1 hypothetical protein -
EC042_RS30710 2345382..2345495 + 114 WP_001161660.1 DUF957 domain-containing protein -
EC042_RS30175 2345784..2345957 - 174 WP_071592185.1 transposase domain-containing protein -
EC042_RS30180 2345984..2346166 + 183 WP_001016348.1 hypothetical protein -
EC042_RS12075 2346267..2346596 - 330 WP_000450409.1 DUF496 family protein -
EC042_RS12080 2346768..2347826 - 1059 WP_001200891.1 FUSC family protein -
EC042_RS12085 2348024..2348497 - 474 WP_001105418.1 DNA gyrase inhibitor SbmC -
EC042_RS12090 2348616..2349782 - 1167 WP_001303036.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T27207 WP_000854814.1 NC_017626:2344804-2345178 [Escherichia coli 042]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T27207 NC_017626:2344804-2345178 [Escherichia coli 042]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT27207 WP_001285585.1 NC_017626:2344347-2344715 [Escherichia coli 042]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT27207 NC_017626:2344347-2344715 [Escherichia coli 042]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References