Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2075166..2075817 Replicon chromosome
Accession NZ_CP117678
Organism Escherichia albertii strain BIA_4

Toxin (Protein)


Gene name cptA Uniprot ID B1EG01
Locus tag PS033_RS10455 Protein ID WP_000244763.1
Coordinates 2075166..2075570 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag PS033_RS10460 Protein ID WP_000354046.1
Coordinates 2075551..2075817 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS033_RS10435 (2071124) 2071124..2072857 - 1734 WP_059221131.1 single-stranded-DNA-specific exonuclease RecJ -
PS033_RS10440 (2072863) 2072863..2073573 - 711 WP_000748106.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PS033_RS10445 (2073598) 2073598..2074494 - 897 WP_059268127.1 site-specific tyrosine recombinase XerD -
PS033_RS10450 (2074606) 2074606..2075127 + 522 WP_059221135.1 flavodoxin FldB -
PS033_RS10455 (2075166) 2075166..2075570 - 405 WP_000244763.1 protein YgfX Toxin
PS033_RS10460 (2075551) 2075551..2075817 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
PS033_RS10465 (2075807) 2075807..2076037 - 231 WP_000181267.1 hypothetical protein -
PS033_RS10470 (2076069) 2076069..2077049 + 981 WP_059221136.1 tRNA-modifying protein YgfZ -
PS033_RS10475 (2077370) 2077370..2078029 - 660 WP_000250281.1 hemolysin III family protein -
PS033_RS10480 (2078197) 2078197..2078508 - 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
PS033_RS10485 (2078553) 2078553..2079986 + 1434 WP_059221179.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15888.81 Da        Isoelectric Point: 11.1732

>T272009 WP_000244763.1 NZ_CP117678:c2075570-2075166 [Escherichia albertii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAAILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVRAPWMIKTGMMLRLLSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIQ

Download         Length: 405 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT272009 WP_000354046.1 NZ_CP117678:c2075817-2075551 [Escherichia albertii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6P9B3

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References