Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 2000190..2000434 Replicon chromosome
Accession NZ_CP117668
Organism Escherichia albertii strain BIA_11

Toxin (Protein)


Gene name hokX Uniprot ID S1PD89
Locus tag PS054_RS10210 Protein ID WP_000956458.1
Coordinates 2000190..2000342 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokX
Locus tag -
Coordinates 2000387..2000434 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS054_RS10200 1995975..1998632 - 2658 WP_059221338.1 CRISPR-associated helicase/endonuclease Cas3 -
PS054_RS10205 1998885..1999997 + 1113 WP_273815331.1 IS4-like element IS421 family transposase -
PS054_RS10210 2000190..2000342 - 153 WP_000956458.1 Hok/Gef family protein Toxin
- 2000387..2000434 + 48 - - Antitoxin
PS054_RS10215 2000606..2001340 - 735 WP_000039850.1 phosphoadenosine phosphosulfate reductase -
PS054_RS10220 2001414..2003126 - 1713 WP_113650311.1 assimilatory sulfite reductase (NADPH) hemoprotein subunit -
PS054_RS10225 2003126..2004925 - 1800 WP_273815335.1 NADPH-dependent assimilatory sulfite reductase flavoprotein subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(5-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5558.77 Da        Isoelectric Point: 7.6757

>T271961 WP_000956458.1 NZ_CP117668:c2000342-2000190 [Escherichia albertii]
MLTKYALVAIIVLCCTVLGFTLMVGDSLCELSIRERGMEFKAVLAYESKK

Download         Length: 153 bp

Antitoxin


Download         Length: 48 bp

>AT271961 NZ_CP117668:2000387-2000434 [Escherichia albertii]
GTTCGAACGTAGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TJ83

Antitoxin

Download structure file

References