Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 2355802..2356406 Replicon chromosome
Accession NZ_CP117659
Organism Escherichia albertii strain BIA_13

Toxin (Protein)


Gene name doc Uniprot ID B1EM00
Locus tag PS034_RS11590 Protein ID WP_000638401.1
Coordinates 2356020..2356406 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID B1ELZ9
Locus tag PS034_RS11585 Protein ID WP_001195490.1
Coordinates 2355802..2356023 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS034_RS11565 (2351045) 2351045..2352679 + 1635 WP_273823045.1 hypothetical protein -
PS034_RS11570 (2352697) 2352697..2352984 + 288 WP_089589836.1 DUF2523 family protein -
PS034_RS11575 (2352996) 2352996..2354054 + 1059 WP_273823047.1 zonular occludens toxin domain-containing protein -
PS034_RS11580 (2354051) 2354051..2355310 + 1260 WP_062863914.1 type II secretion system protein GspD -
PS034_RS11585 (2355802) 2355802..2356023 + 222 WP_001195490.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PS034_RS11590 (2356020) 2356020..2356406 + 387 WP_000638401.1 type II toxin-antitoxin system death-on-curing family toxin Toxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(3-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14505.49 Da        Isoelectric Point: 8.0833

>T271928 WP_000638401.1 NZ_CP117659:2356020-2356406 [Escherichia albertii]
MIWVSAQEVIAFHDRILQRFPGVAGLTDPGRAQALIYRVQNRVHYEGVTDLFELAATYWVAIARGHIFHDGNKRTAFFVT
MTFLWRNGIRIRDVDNSLENLTVEAATGEKTVGQLARCLRERVDSSGN

Download         Length: 387 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8067.96 Da        Isoelectric Point: 4.6816

>AT271928 WP_001195490.1 NZ_CP117659:2355802-2356023 [Escherichia albertii]
MQTYTSTQARANIATVLDTALNGEPVEITRRDGSSAVLISKAAFEAYQNAKLDAEFDAIMQRHEHTIEALTDR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T5VDW2

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6PD20

References