Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 4349363..4350163 Replicon chromosome
Accession NZ_CP117628
Organism Escherichia albertii strain BIA_22

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag PS041_RS21775 Protein ID WP_059228514.1
Coordinates 4349363..4349890 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID B1EHP0
Locus tag PS041_RS21780 Protein ID WP_001277106.1
Coordinates 4349897..4350163 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS041_RS21750 (4344438) 4344438..4345205 - 768 WP_000082094.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
PS041_RS21755 (4345202) 4345202..4346479 - 1278 WP_059225128.1 branched chain amino acid ABC transporter permease LivM -
PS041_RS21760 (4346476) 4346476..4347402 - 927 WP_001295111.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
PS041_RS21765 (4347450) 4347450..4348559 - 1110 WP_059256853.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
PS041_RS21770 (4348983) 4348983..4349366 + 384 WP_000778774.1 aspartate 1-decarboxylase autocleavage activator PanM -
PS041_RS21775 (4349363) 4349363..4349890 - 528 WP_059228514.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
PS041_RS21780 (4349897) 4349897..4350163 - 267 WP_001277106.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
PS041_RS21785 (4350313) 4350313..4351416 - 1104 WP_273824548.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
PS041_RS21790 (4351938) 4351938..4352339 + 402 WP_001071334.1 PTS sugar transporter subunit IIA -
PS041_RS21795 (4352346) 4352346..4352831 + 486 WP_000029259.1 PTS sugar transporter subunit IIB -
PS041_RS21800 (4352848) 4352848..4353594 + 747 WP_000151888.1 PTS sugar transporter subunit IIC -
PS041_RS21805 (4353587) 4353587..4354441 + 855 WP_000370584.1 PTS system mannose/fructose/sorbose family transporter subunit IID -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(90-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19623.53 Da        Isoelectric Point: 6.6303

>T271773 WP_059228514.1 NZ_CP117628:c4349890-4349363 [Escherichia albertii]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPECQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9942.37 Da        Isoelectric Point: 10.0863

>AT271773 WP_001277106.1 NZ_CP117628:c4350163-4349897 [Escherichia albertii]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7Z8E004

References