Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 2215807..2216411 Replicon chromosome
Accession NZ_CP117628
Organism Escherichia albertii strain BIA_22

Toxin (Protein)


Gene name doc Uniprot ID B1EM00
Locus tag PS041_RS11085 Protein ID WP_000638401.1
Coordinates 2215807..2216193 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID B1ELZ9
Locus tag PS041_RS11090 Protein ID WP_001195490.1
Coordinates 2216190..2216411 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS041_RS11070 (2212175) 2212175..2214814 + 2640 WP_273825412.1 autotransporter-associated beta strand repeat-containing protein -
PS041_RS11075 (2214807) 2214807..2215163 + 357 WP_273825414.1 autotransporter outer membrane beta-barrel domain-containing protein -
PS041_RS11080 (2215200) 2215200..2215727 + 528 WP_273825416.1 autotransporter outer membrane beta-barrel domain-containing protein -
PS041_RS11085 (2215807) 2215807..2216193 - 387 WP_000638401.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
PS041_RS11090 (2216190) 2216190..2216411 - 222 WP_001195490.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PS041_RS11095 (2216753) 2216753..2217560 + 808 Protein_2159 helix-turn-helix domain-containing protein -
PS041_RS11100 (2217775) 2217775..2219127 + 1353 WP_273825417.1 SIR2 family protein -
PS041_RS11105 (2219449) 2219449..2220207 + 759 WP_054410601.1 trans-aconitate 2-methyltransferase -
PS041_RS11110 (2220211) 2220211..2221125 - 915 WP_024164792.1 bestrophin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2206952..2236401 29449
- flank IS/Tn - - 2217174..2217560 386


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(3-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14505.49 Da        Isoelectric Point: 8.0833

>T271767 WP_000638401.1 NZ_CP117628:c2216193-2215807 [Escherichia albertii]
MIWVSAQEVIAFHDRILQRFPGVAGLTDPGRAQALIYRVQNRVHYEGVTDLFELAATYWVAIARGHIFHDGNKRTAFFVT
MTFLWRNGIRIRDVDNSLENLTVEAATGEKTVGQLARCLRERVDSSGN

Download         Length: 387 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8067.96 Da        Isoelectric Point: 4.6816

>AT271767 WP_001195490.1 NZ_CP117628:c2216411-2216190 [Escherichia albertii]
MQTYTSTQARANIATVLDTALNGEPVEITRRDGSSAVLISKAAFEAYQNAKLDAEFDAIMQRHEHTIEALTDR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T5VDW2

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6PD20

References