Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 4034733..4035532 Replicon chromosome
Accession NZ_CP117620
Organism Escherichia albertii strain BIA_24

Toxin (Protein)


Gene name yhaV Uniprot ID A0A8H9C2I0
Locus tag PS039_RS19510 Protein ID WP_059227548.1
Coordinates 4035068..4035532 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag PS039_RS19505 Protein ID WP_001296435.1
Coordinates 4034733..4035068 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS039_RS19490 (4030522) 4030522..4031292 - 771 WP_001058056.1 2-dehydro-3-deoxyglucarate aldolase -
PS039_RS19495 (4031308) 4031308..4032642 - 1335 WP_273809737.1 galactarate/glucarate/glycerate transporter GarP -
PS039_RS19500 (4033013) 4033013..4034584 + 1572 WP_273809738.1 galactarate dehydratase -
PS039_RS19505 (4034733) 4034733..4035068 + 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
PS039_RS19510 (4035068) 4035068..4035532 + 465 WP_059227548.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
PS039_RS19515 (4035587) 4035587..4036396 - 810 WP_000072169.1 aga operon transcriptional regulator AgaR -
PS039_RS19520 (4036645) 4036645..4037925 + 1281 WP_059235447.1 tagatose-bisphosphate aldolase subunit KbaZ -
PS039_RS19525 (4037948) 4037948..4038421 + 474 WP_002461030.1 PTS N-acetylgalactosamine transporter subunit IIB -
PS039_RS19530 (4038432) 4038432..4039211 + 780 WP_000406226.1 PTS N-acetylgalactosamine transporter subunit IIC -
PS039_RS19535 (4039201) 4039201..4040079 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
PS039_RS19540 (4040097) 4040097..4040531 + 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17819.26 Da        Isoelectric Point: 9.7301

>T271746 WP_059227548.1 NZ_CP117620:4035068-4035532 [Escherichia albertii]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRFRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTQETEEKH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT271746 WP_001296435.1 NZ_CP117620:4034733-4035068 [Escherichia albertii]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References