Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3528561..3528807 Replicon chromosome
Accession NZ_CP117620
Organism Escherichia albertii strain BIA_24

Toxin (Protein)


Gene name hokX Uniprot ID S1PD89
Locus tag PS039_RS17140 Protein ID WP_000956458.1
Coordinates 3528561..3528713 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokX
Locus tag -
Coordinates 3528755..3528807 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS039_RS17115 3523829..3524152 - 324 WP_273809518.1 DUF3561 family protein -
PS039_RS17120 3524202..3524807 - 606 WP_024164993.1 adenylyl-sulfate kinase -
PS039_RS17125 3524807..3526234 - 1428 WP_141109490.1 sulfate adenylyltransferase subunit CysN -
PS039_RS17130 3526236..3527144 - 909 WP_000372386.1 sulfate adenylyltransferase subunit CysD -
PS039_RS17135 3527398..3528435 + 1038 WP_059268554.1 alkaline phosphatase isozyme conversion aminopeptidase -
PS039_RS17140 3528561..3528713 - 153 WP_000956458.1 Hok/Gef family protein Toxin
- 3528755..3528807 + 53 - - Antitoxin
PS039_RS17145 3528978..3529712 - 735 WP_001125132.1 phosphoadenosine phosphosulfate reductase -
PS039_RS17150 3529892..3531604 - 1713 WP_059273794.1 assimilatory sulfite reductase (NADPH) hemoprotein subunit -
PS039_RS17155 3531604..3533403 - 1800 WP_273809520.1 NADPH-dependent assimilatory sulfite reductase flavoprotein subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(5-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5558.77 Da        Isoelectric Point: 7.6757

>T271743 WP_000956458.1 NZ_CP117620:c3528713-3528561 [Escherichia albertii]
MLTKYALVAIIVLCCTVLGFTLMVGDSLCELSIRERGMEFKAVLAYESKK

Download         Length: 153 bp

Antitoxin


Download         Length: 53 bp

>AT271743 NZ_CP117620:3528755-3528807 [Escherichia albertii]
TTAGGTTCGAACGCTGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TJ83

Antitoxin

Download structure file

References