Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2200515..2201077 Replicon chromosome
Accession NZ_CP117620
Organism Escherichia albertii strain BIA_24

Toxin (Protein)


Gene name higB Uniprot ID A0A8H9EY56
Locus tag PS039_RS10570 Protein ID WP_059219270.1
Coordinates 2200799..2201077 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag PS039_RS10565 Protein ID WP_000781370.1
Coordinates 2200515..2200799 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS039_RS10550 (2195697) 2195697..2198744 + 3048 WP_077776584.1 formate dehydrogenase-N subunit alpha -
PS039_RS10555 (2198757) 2198757..2199641 + 885 WP_001240583.1 formate dehydrogenase N subunit beta -
PS039_RS10560 (2199634) 2199634..2200287 + 654 WP_000045636.1 formate dehydrogenase-N subunit gamma -
PS039_RS10565 (2200515) 2200515..2200799 - 285 WP_000781370.1 HigA family addiction module antitoxin Antitoxin
PS039_RS10570 (2200799) 2200799..2201077 - 279 WP_059219270.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PS039_RS10575 (2201263) 2201263..2202273 - 1011 WP_059219269.1 alcohol dehydrogenase AdhP -
PS039_RS10580 (2202408) 2202408..2204105 - 1698 WP_000433442.1 malate dehydrogenase -
PS039_RS10585 (2204262) 2204262..2204399 - 138 WP_000841563.1 stationary-phase-induced ribosome-associated protein -
PS039_RS10590 (2204666) 2204666..2205097 + 432 WP_000152289.1 peroxiredoxin OsmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10505.04 Da        Isoelectric Point: 7.3995

>T271737 WP_059219270.1 NZ_CP117620:c2201077-2200799 [Escherichia albertii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASSLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT271737 WP_000781370.1 NZ_CP117620:c2200799-2200515 [Escherichia albertii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References