Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1091021..1091639 Replicon chromosome
Accession NZ_CP117620
Organism Escherichia albertii strain BIA_24

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PS039_RS05180 Protein ID WP_001280991.1
Coordinates 1091021..1091239 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B1EKM5
Locus tag PS039_RS05185 Protein ID WP_000344798.1
Coordinates 1091265..1091639 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS039_RS05145 (1086310) 1086310..1086882 + 573 WP_000779847.1 YbaY family lipoprotein -
PS039_RS05150 (1086912) 1086912..1087223 - 312 WP_273810347.1 MGMT family protein -
PS039_RS05160 (1087604) 1087604..1087957 + 354 WP_000878151.1 DUF1428 family protein -
PS039_RS05165 (1087995) 1087995..1089545 - 1551 WP_001260378.1 EAL domain-containing protein -
PS039_RS05170 (1089709) 1089709..1090179 - 471 WP_000136188.1 YlaC family protein -
PS039_RS05175 (1090287) 1090287..1090844 - 558 WP_025237467.1 maltose O-acetyltransferase -
PS039_RS05180 (1091021) 1091021..1091239 - 219 WP_001280991.1 HHA domain-containing protein Toxin
PS039_RS05185 (1091265) 1091265..1091639 - 375 WP_000344798.1 Hha toxicity modulator TomB Antitoxin
PS039_RS05190 (1092194) 1092194..1095343 - 3150 WP_273810348.1 efflux RND transporter permease AcrB -
PS039_RS05195 (1095366) 1095366..1096559 - 1194 WP_010334435.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T271731 WP_001280991.1 NZ_CP117620:c1091239-1091021 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14499.35 Da        Isoelectric Point: 4.8989

>AT271731 WP_000344798.1 NZ_CP117620:c1091639-1091265 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3RX90

References