Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-OrzO/SymE(toxin)
Location 3877977..3878389 Replicon chromosome
Accession NZ_CP117609
Organism Escherichia albertii strain BIA_26

Toxin (Protein)


Gene name symE Uniprot ID A0A7U8ZC55
Locus tag PS038_RS18570 Protein ID WP_025237738.1
Coordinates 3878048..3878389 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name OrzO
Locus tag -
Coordinates 3877977..3878053 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS038_RS18560 (3874894) 3874894..3876483 + 1590 WP_059218507.1 type I restriction-modification system methyltransferase -
PS038_RS18565 (3876480) 3876480..3877820 + 1341 WP_059218508.1 restriction endonuclease subunit S -
- (3877977) 3877977..3878053 - 77 NuclAT_6 - Antitoxin
- (3877977) 3877977..3878053 - 77 NuclAT_6 - Antitoxin
- (3877977) 3877977..3878053 - 77 NuclAT_6 - Antitoxin
- (3877977) 3877977..3878053 - 77 NuclAT_6 - Antitoxin
- (3877977) 3877977..3878053 - 77 NuclAT_7 - Antitoxin
- (3877977) 3877977..3878053 - 77 NuclAT_7 - Antitoxin
- (3877977) 3877977..3878053 - 77 NuclAT_7 - Antitoxin
- (3877977) 3877977..3878053 - 77 NuclAT_7 - Antitoxin
PS038_RS18570 (3878048) 3878048..3878389 + 342 WP_025237738.1 endoribonuclease SymE Toxin
PS038_RS18575 (3878551) 3878551..3879930 + 1380 WP_059218509.1 5-methylcytosine-specific restriction endonuclease subunit McrB -
PS038_RS18580 (3879930) 3879930..3880976 + 1047 WP_072248752.1 5-methylcytosine-specific restriction endonuclease system specificity protein McrC -
PS038_RS18585 (3881032) 3881032..3882110 - 1079 Protein_3631 DUF1998 domain-containing protein -
PS038_RS18590 (3882427) 3882427..3883359 - 933 WP_273818182.1 Rpn family recombination-promoting nuclease/putative transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12310.12 Da        Isoelectric Point: 7.8219

>T271689 WP_025237738.1 NZ_CP117609:3878048-3878389 [Escherichia albertii]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAIDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQEFIGVIAGKQKVA

Download         Length: 342 bp

Antitoxin


Download         Length: 77 bp

>AT271689 NZ_CP117609:c3878053-3877977 [Escherichia albertii]
AGTCATGATTACTATTCTCCATAAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U8ZC55

Antitoxin

Download structure file

References