Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 1281288..1281892 Replicon chromosome
Accession NZ_CP117606
Organism Escherichia albertii strain BIA_29

Toxin (Protein)


Gene name doc Uniprot ID B1EM00
Locus tag PS031_RS06190 Protein ID WP_000638401.1
Coordinates 1281288..1281674 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID B1ELZ9
Locus tag PS031_RS06195 Protein ID WP_001195490.1
Coordinates 1281671..1281892 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS031_RS06170 (1277903) 1277903..1279063 - 1161 WP_059236629.1 anaerobic sulfatase maturase -
PS031_RS06175 (1279117) 1279117..1279554 - 438 Protein_1207 sulfatase -
PS031_RS06180 (1279836) 1279836..1280144 + 309 WP_273772611.1 autotransporter outer membrane beta-barrel domain-containing protein -
PS031_RS06185 (1280135) 1280135..1281208 + 1074 Protein_1209 autotransporter outer membrane beta-barrel domain-containing protein -
PS031_RS06190 (1281288) 1281288..1281674 - 387 WP_000638401.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
PS031_RS06195 (1281671) 1281671..1281892 - 222 WP_001195490.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PS031_RS06200 (1281989) 1281989..1282870 - 882 WP_204629406.1 LysR family transcriptional regulator -
PS031_RS06205 (1282971) 1282971..1284359 + 1389 WP_098401985.1 succinate-semialdehyde dehydrogenase -
PS031_RS06210 (1284423) 1284423..1285349 + 927 WP_000257427.1 glutaminase B -
PS031_RS06215 (1285349) 1285349..1285711 + 363 WP_001257078.1 DUF4186 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(3-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14505.49 Da        Isoelectric Point: 8.0833

>T271649 WP_000638401.1 NZ_CP117606:c1281674-1281288 [Escherichia albertii]
MIWVSAQEVIAFHDRILQRFPGVAGLTDPGRAQALIYRVQNRVHYEGVTDLFELAATYWVAIARGHIFHDGNKRTAFFVT
MTFLWRNGIRIRDVDNSLENLTVEAATGEKTVGQLARCLRERVDSSGN

Download         Length: 387 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8067.96 Da        Isoelectric Point: 4.6816

>AT271649 WP_001195490.1 NZ_CP117606:c1281892-1281671 [Escherichia albertii]
MQTYTSTQARANIATVLDTALNGEPVEITRRDGSSAVLISKAAFEAYQNAKLDAEFDAIMQRHEHTIEALTDR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T5VDW2

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6PD20

References