Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1263577..1264139 Replicon chromosome
Accession NZ_CP117606
Organism Escherichia albertii strain BIA_29

Toxin (Protein)


Gene name higB Uniprot ID L4J948
Locus tag PS031_RS06115 Protein ID WP_000605676.1
Coordinates 1263861..1264139 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PS031_RS06110 Protein ID WP_000781369.1
Coordinates 1263577..1263861 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS031_RS06095 (1261493) 1261493..1262377 + 885 WP_001240583.1 formate dehydrogenase N subunit beta -
PS031_RS06100 (1262370) 1262370..1263023 + 654 WP_000045636.1 formate dehydrogenase-N subunit gamma -
PS031_RS06105 (1263096) 1263096..1263572 + 477 WP_059225294.1 NUDIX domain-containing protein -
PS031_RS06110 (1263577) 1263577..1263861 - 285 WP_000781369.1 HigA family addiction module antitoxin Antitoxin
PS031_RS06115 (1263861) 1263861..1264139 - 279 WP_000605676.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PS031_RS06120 (1264325) 1264325..1265335 - 1011 WP_059225293.1 alcohol dehydrogenase AdhP -
PS031_RS06125 (1265469) 1265469..1267166 - 1698 WP_059225292.1 malate dehydrogenase -
PS031_RS06130 (1267323) 1267323..1267460 - 138 WP_000841563.1 stationary-phase-induced ribosome-associated protein -
PS031_RS06135 (1267727) 1267727..1268158 + 432 WP_262931862.1 peroxiredoxin OsmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(3-81)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10521.10 Da        Isoelectric Point: 7.3562

>T271648 WP_000605676.1 NZ_CP117606:c1264139-1263861 [Escherichia albertii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10371.06 Da        Isoelectric Point: 8.8567

>AT271648 WP_000781369.1 NZ_CP117606:c1263861-1263577 [Escherichia albertii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVAQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829G6T1

Antitoxin

Source ID Structure

References