Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2419554..2420116 Replicon chromosome
Accession NZ_CP117590
Organism Escherichia albertii strain BIA_36

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PS051_RS12175 Protein ID WP_059276333.1
Coordinates 2419554..2419832 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag PS051_RS12180 Protein ID WP_000781370.1
Coordinates 2419832..2420116 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS051_RS12155 (2415549) 2415549..2415980 - 432 WP_273780723.1 peroxiredoxin OsmC -
PS051_RS12160 (2416238) 2416238..2416375 + 138 WP_273780724.1 stationary-phase-induced ribosome-associated protein -
PS051_RS12165 (2416526) 2416526..2418223 + 1698 WP_000433442.1 malate dehydrogenase -
PS051_RS12170 (2418358) 2418358..2419368 + 1011 WP_000642385.1 alcohol dehydrogenase AdhP -
PS051_RS12175 (2419554) 2419554..2419832 + 279 WP_059276333.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PS051_RS12180 (2419832) 2419832..2420116 + 285 WP_000781370.1 HigA family addiction module antitoxin Antitoxin
PS051_RS12185 (2420345) 2420345..2420998 - 654 WP_000045636.1 formate dehydrogenase-N subunit gamma -
PS051_RS12190 (2420991) 2420991..2421875 - 885 WP_273780725.1 formate dehydrogenase N subunit beta -
PS051_RS12195 (2421888) 2421888..2424935 - 3048 WP_077870794.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10481.08 Da        Isoelectric Point: 7.2751

>T271571 WP_059276333.1 NZ_CP117590:2419554-2419832 [Escherichia albertii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASCLADIDMPGYRLPPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT271571 WP_000781370.1 NZ_CP117590:2419832-2420116 [Escherichia albertii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References