Detailed information of TA system TA027150

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 22262..22784
• Replicon: plasmid pB182_37
• Accession: NC_017624
• Organism: Salmonella enterica subsp. enterica serovar Heidelberg str. B182

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G3CAN5
• Locus tag: SU5_RS23095
• Protein ID: WP_000220560.1
• Coordinates: 22262..22543 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G3CAG1
• Locus tag: SU5_RS23100
• Protein ID: WP_000121743.1
• Coordinates: 22533..22784 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SU5_RS23060	18110..19276	-	1167	WP_000539532.1	relaxase/mobilization nuclease domain-containing protein	-
SU5_RS23065	19279..19824	-	546	WP_000757693.1	hypothetical protein	-
SU5_RS25640	19819..19893	-	75	Protein_22	DNA distortion polypeptide 3	-
SU5_RS24725	20150..20422	-	273	WP_000160399.1	hypothetical protein	-
SU5_RS25510	20435..20632	-	198	WP_001675595.1	hypothetical protein	-
SU5_RS24730	20654..20833	-	180	WP_000439078.1	hypothetical protein	-
SU5_RS23075	20876..21205	-	330	WP_000866646.1	hypothetical protein	-
SU5_RS23080	21298..21513	-	216	WP_001180116.1	hypothetical protein	-
SU5_RS23085	21503..21748	-	246	WP_000356547.1	hypothetical protein	-
SU5_RS23090	21793..22116	-	324	WP_001181903.1	hypothetical protein	-
SU5_RS23095	22262..22543	-	282	WP_000220560.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SU5_RS23100	22533..22784	-	252	WP_000121743.1	plasmid stabilization protein	Antitoxin
SU5_RS25645	24856..25068	+	213	WP_187287346.1	hypothetical protein	-
SU5_RS23110	25241..25657	+	417	WP_000202943.1	hypothetical protein	-
SU5_RS23115	25654..26631	-	978	WP_001269910.1	hypothetical protein	-
SU5_RS23120	26656..26937	-	282	WP_001185482.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..37581	37581

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 13852.62 Da
• Isoelectric Point: 5.5500

>T27150 WP_000220560.1 NC_017624:c22543-22262 [Salmonella enterica subsp. enterica serovar Heidelberg str. B182]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFF

Nucleotide

• Length: 282 bp

>T27150 NC_017624:c22543-22262 [Salmonella enterica subsp. enterica serovar Heidelberg str. B182]
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TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
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Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 12380.85 Da
• Isoelectric Point: 5.5500

>AT27150 WP_000121743.1 NC_017624:c22784-22533 [Salmonella enterica subsp. enterica serovar Heidelberg str. B182]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFF

Nucleotide

• Length: 252 bp

>AT27150 NC_017624:c22784-22533 [Salmonella enterica subsp. enterica serovar Heidelberg str. B182]
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TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
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Structures

Toxin

• AlphaFold DB: G3CAN5

Antitoxin

• AlphaFold DB: A0A3S5I301