Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yeeU/CbtA-CbeA
Location 4017053..4017760 Replicon chromosome
Accession NZ_CP117570
Organism Escherichia albertii strain BIA_50

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag PS035_RS19355 Protein ID WP_161537416.1
Coordinates 4017053..4017394 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3L1KVZ6
Locus tag PS035_RS19360 Protein ID WP_000939437.1
Coordinates 4017425..4017760 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS035_RS19330 (4013336) 4013336..4014319 - 984 WP_161537412.1 restriction endonuclease -
PS035_RS19335 (4014591) 4014591..4015382 - 792 WP_161537413.1 helix-turn-helix transcriptional regulator -
PS035_RS19340 (4015501) 4015501..4015776 - 276 WP_161537414.1 type II toxin-antitoxin system RelE/ParE family toxin -
PS035_RS19345 (4015780) 4015780..4016028 - 249 WP_024187601.1 ribbon-helix-helix domain-containing protein -
PS035_RS19350 (4016105) 4016105..4016938 - 834 WP_161537415.1 DUF4942 domain-containing protein -
PS035_RS19355 (4017053) 4017053..4017394 - 342 WP_161537416.1 TA system toxin CbtA family protein Toxin
PS035_RS19360 (4017425) 4017425..4017760 - 336 WP_000939437.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
PS035_RS19365 (4017760) 4017760..4018233 - 474 WP_161537417.1 DNA repair protein RadC -
PS035_RS19370 (4018263) 4018263..4019081 - 819 WP_161537418.1 DUF932 domain-containing protein -
PS035_RS19375 (4019625) 4019625..4020269 - 645 WP_237579909.1 hypothetical protein -
PS035_RS19380 (4020862) 4020862..4021278 + 417 WP_273817457.1 inovirus-type Gp2 protein -
PS035_RS19385 (4021354) 4021354..4022582 + 1229 WP_183042231.1 IS3-like element IS2 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - vat 4002871..4037419 34548


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-110)

Antitoxin

Antitoxin CbeA

(10-110)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13049.02 Da        Isoelectric Point: 9.5454

>T271463 WP_161537416.1 NZ_CP117570:c4017394-4017053 [Escherichia albertii]
MKIIPATTLRATTSYLSPVVVWQTLLARLLEQHYGLNLNDTPFNNEKVIQEHIDAGITLVDAVNFLVEKYELIRIDRKGF
SWQEQTPYLRAVDILRARQATGQLRRCHNTTAR

Download         Length: 342 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12556.56 Da        Isoelectric Point: 7.6977

>AT271463 WP_000939437.1 NZ_CP117570:c4017760-4017425 [Escherichia albertii]
MLQKDKVMQQEWGLPCTVTPRFTARLVQERHNLHYLADRAAITGKFSSPDLLHIDQAFPVLMKQLELKLADGELSPCQQR
TVTLYAKGLTCEADTLGSCGYVYIAIYPTQR

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3L1KVZ6

References