Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 906674..907325 Replicon chromosome
Accession NZ_CP117570
Organism Escherichia albertii strain BIA_50

Toxin (Protein)


Gene name cptA Uniprot ID B1EG01
Locus tag PS035_RS04400 Protein ID WP_000244763.1
Coordinates 906921..907325 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag PS035_RS04395 Protein ID WP_000354046.1
Coordinates 906674..906940 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS035_RS04370 (902386) 902386..903819 - 1434 WP_024164724.1 6-phospho-beta-glucosidase BglA -
PS035_RS04375 (903864) 903864..904175 + 312 WP_273817723.1 N(4)-acetylcytidine aminohydrolase -
PS035_RS04380 (904343) 904343..905002 + 660 WP_000250281.1 hemolysin III family protein -
PS035_RS04385 (905442) 905442..906422 - 981 WP_273817724.1 tRNA-modifying protein YgfZ -
PS035_RS04390 (906454) 906454..906684 + 231 WP_000181267.1 hypothetical protein -
PS035_RS04395 (906674) 906674..906940 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
PS035_RS04400 (906921) 906921..907325 + 405 WP_000244763.1 protein YgfX Toxin
PS035_RS04405 (907364) 907364..907885 - 522 WP_125060507.1 flavodoxin FldB -
PS035_RS04410 (907997) 907997..908893 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
PS035_RS04415 (908918) 908918..909628 + 711 WP_000748105.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PS035_RS04420 (909634) 909634..911367 + 1734 WP_273817726.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15888.81 Da        Isoelectric Point: 11.1732

>T271449 WP_000244763.1 NZ_CP117570:906921-907325 [Escherichia albertii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAAILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVRAPWMIKTGMMLRLLSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIQ

Download         Length: 405 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT271449 WP_000354046.1 NZ_CP117570:906674-906940 [Escherichia albertii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6P9B3

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References