Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 661554..662281 Replicon chromosome
Accession NZ_CP117556
Organism Escherichia albertii strain BIA_89-5

Toxin (Protein)


Gene name higB Uniprot ID U9ZMR4
Locus tag PS032_RS03360 Protein ID WP_000550189.1
Coordinates 661554..661868 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PS032_RS03365 Protein ID WP_000560272.1
Coordinates 661865..662281 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS032_RS03340 (657713) 657713..658699 - 987 WP_059216461.1 Gfo/Idh/MocA family oxidoreductase -
PS032_RS03345 (658778) 658778..659470 - 693 WP_059216460.1 vancomycin high temperature exclusion protein -
PS032_RS03350 (659547) 659547..660050 - 504 WP_059216459.1 M48 family metallopeptidase -
PS032_RS03355 (660135) 660135..661271 + 1137 WP_000018669.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
PS032_RS03360 (661554) 661554..661868 + 315 WP_000550189.1 type II toxin-antitoxin system toxin HigB Toxin
PS032_RS03365 (661865) 661865..662281 + 417 WP_000560272.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
PS032_RS03370 (662371) 662371..664388 - 2018 Protein_659 NADPH-dependent 2,4-dienoyl-CoA reductase -
PS032_RS03375 (664615) 664615..666966 - 2352 WP_137653395.1 alpha-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-135)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12103.10 Da        Isoelectric Point: 10.0409

>T271334 WP_000550189.1 NZ_CP117556:661554-661868 [Escherichia albertii]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK

Download         Length: 315 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 14993.40 Da        Isoelectric Point: 4.3697

>AT271334 WP_000560272.1 NZ_CP117556:661865-662281 [Escherichia albertii]
MIAIADILQAGEKLTDVAPFLAGIQSEEQYAQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMVQAMPGG
VAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLNGKRKLTLEHAKKLAARFGISPALFID

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6KMQ
PDB 5IFG
PDB 5YCL
PDB 6KML

Antitoxin

Source ID Structure

References