Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1084037..1084664 Replicon chromosome
Accession NZ_CP117554
Organism Erwinia amylovora strain 99east-3-1

Toxin (Protein)


Gene name Hha Uniprot ID D2T444
Locus tag PTC76_RS04995 Protein ID WP_004156337.1
Coordinates 1084037..1084255 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag PTC76_RS05000 Protein ID WP_013035913.1
Coordinates 1084275..1084664 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC76_RS04965 (PTC76_04965) 1080023..1080361 + 339 WP_004156319.1 P-II family nitrogen regulator -
PTC76_RS04970 (PTC76_04970) 1080379..1081680 + 1302 WP_004172214.1 ammonium transporter AmtB -
PTC76_RS04975 (PTC76_04975) 1081755..1082615 - 861 WP_004156324.1 acyl-CoA thioesterase II -
PTC76_RS04980 (PTC76_04980) 1082840..1083397 + 558 WP_004156333.1 YbaY family lipoprotein -
PTC76_RS04985 (PTC76_04985) 1083420..1083737 - 318 WP_168397246.1 MGMT family protein -
PTC76_RS04995 (PTC76_04995) 1084037..1084255 - 219 WP_004156337.1 HHA domain-containing protein Toxin
PTC76_RS05000 (PTC76_05000) 1084275..1084664 - 390 WP_013035913.1 Hha toxicity modulator TomB Antitoxin
PTC76_RS05005 (PTC76_05005) 1084811..1085164 - 354 WP_004156342.1 hypothetical protein -
PTC76_RS05010 (PTC76_05010) 1085936..1086082 - 147 WP_004156349.1 type B 50S ribosomal protein L36 -
PTC76_RS05015 (PTC76_05015) 1086070..1086351 - 282 WP_004156350.1 type B 50S ribosomal protein L31 -
PTC76_RS05020 (PTC76_05020) 1086499..1089645 - 3147 WP_004156353.1 multidrug efflux RND transporter permease subunit AcrB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8627.06 Da        Isoelectric Point: 8.9007

>T271324 WP_004156337.1 NZ_CP117554:c1084255-1084037 [Erwinia amylovora]
MTDKLLTKTDYLMRLRRCRSIDTLERVIEKNKYELSDDELAVFYSAADHRLAELTMNKLYDKVPVAVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 14965.70 Da        Isoelectric Point: 4.7040

>AT271324 WP_013035913.1 NZ_CP117554:c1084664-1084275 [Erwinia amylovora]
MDEYSPKRHDIAQLKFLCENLYDESLATLGDSHHGWVNDPTSTSNLQLNDLIEHIAAFTMNYKIKHIEDSDLISQIDEYL
DDTFMLFSNYGVNNLDLQRWQKSAKRLFNIFAKECVMSQIQSSHSFSSP

Download         Length: 390 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A831EPQ0

Antitoxin

Source ID Structure

References