Detailed information of TA system TA271108

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3690470..3690820
• Replicon: chromosome
• Accession: NZ_CP117394
• Organism: Salmonella enterica subsp. enterica serovar Uganda strain RM017

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3X9ZUV0
• Locus tag: PQP77_RS18275
• Protein ID: WP_000994229.1
• Coordinates: 3690563..3690820 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3690470..3690738 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PQP77_RS18245	3685582..3685959	-	378	WP_000739707.1	Imm8 family immunity protein	-
PQP77_RS18250	3686692..3687057	-	366	WP_001231281.1	hypothetical protein	-
PQP77_RS18255	3687023..3688369	-	1347	Protein_3571	RHS repeat-associated core domain-containing protein	-
PQP77_RS18260	3688431..3688688	+	258	WP_000994229.1	SymE family type I addiction module toxin	-
PQP77_RS18265	3688752..3689090	-	339	WP_000382983.1	hypothetical protein	-
PQP77_RS18270	3689461..3690501	-	1041	Protein_3574	RHS repeat-associated core domain-containing protein	-
-	3690470..3690738	-	269	-	-	Antitoxin
PQP77_RS18275	3690563..3690820	+	258	WP_000994229.1	SymE family type I addiction module toxin	Toxin
PQP77_RS18280	3690884..3691222	-	339	WP_000382983.1	hypothetical protein	-
PQP77_RS18285	3691593..3693350	-	1758	Protein_3577	RHS repeat domain-containing protein	-
PQP77_RS18290	3693555..3693788	+	234	WP_000035941.1	hypothetical protein	-
PQP77_RS18295	3693860..3694207	-	348	WP_000887296.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3666573..3694231	27658

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9538.91 Da
• Isoelectric Point: 7.2759

>T271108 WP_000994229.1 NZ_CP117394:3690563-3690820 [Salmonella enterica subsp. enterica serovar Uganda]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFETGRGVTVKISQGCIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Nucleotide

• Length: 258 bp

Antitoxin

Nucleotide

• Length: 269 bp

>AT271108 NZ_CP117394:c3690738-3690470 [Salmonella enterica subsp. enterica serovar Uganda]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTCACGCCGCGCCCGGTCTCAAATCCCGCTTCTTCCAGCCA
GTCACCCTTAAGGTGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGAGCGCGACAGCCTGCACCG

Structures

Toxin

• AlphaFold DB: A0A3X9ZUV0

Antitoxin