Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1429352..1429811 Replicon chromosome
Accession NC_017595
Organism Streptococcus salivarius JIM8777

Toxin (Protein)


Gene name relE Uniprot ID F8LI54
Locus tag SALIVA_RS06820 Protein ID WP_013990357.1
Coordinates 1429352..1429606 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID F8HC66
Locus tag SALIVA_RS06825 Protein ID WP_014632927.1
Coordinates 1429596..1429811 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SALIVA_RS06795 1425205..1425975 - 771 WP_014634724.1 hypothetical protein -
SALIVA_RS06800 1426072..1426947 - 876 WP_014634725.1 HAMP domain-containing histidine kinase -
SALIVA_RS06805 1426947..1427630 - 684 WP_014634726.1 response regulator transcription factor -
SALIVA_RS06810 1427798..1428430 - 633 WP_014634727.1 nitroreductase family protein -
SALIVA_RS06815 1428521..1429207 - 687 WP_004182263.1 DUF1275 domain-containing protein -
SALIVA_RS06820 1429352..1429606 - 255 WP_013990357.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SALIVA_RS06825 1429596..1429811 - 216 WP_014632927.1 hypothetical protein Antitoxin
SALIVA_RS06830 1429944..1430786 - 843 WP_014634728.1 aldo/keto reductase -
SALIVA_RS06835 1430895..1431519 - 625 Protein_1301 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-57)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9862.61 Da        Isoelectric Point: 11.1183

>T27106 WP_013990357.1 NC_017595:c1429606-1429352 [Streptococcus salivarius JIM8777]
MTYKIVPTPKFAKSFKKLDPFVRKQIKSYLNRVTDNPRAKGKALVANRTGQWRYRIGAYRVIVNIQDNELIILALEVGHR
RDIY

Download         Length: 255 bp

>T27106 NC_017595:c1429606-1429352 [Streptococcus salivarius JIM8777]
ATGACCTATAAGATAGTACCCACCCCTAAATTTGCCAAAAGTTTTAAAAAGTTGGATCCTTTCGTCAGAAAACAAATTAA
GTCTTATCTCAATCGTGTCACAGATAATCCAAGAGCCAAGGGTAAGGCCTTGGTTGCCAATCGCACTGGACAATGGCGCT
ATCGTATTGGTGCCTATCGTGTTATTGTCAATATTCAGGACAATGAACTAATCATACTTGCCCTCGAAGTCGGTCATAGA
CGTGATATCTATTAG

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8031.00 Da        Isoelectric Point: 3.8964

>AT27106 WP_014632927.1 NC_017595:c1429811-1429596 [Streptococcus salivarius JIM8777]
MTTITLKVSEADKKFMQAIAKFEGVSLSELIRTKTLEAIEDEYDARVADLALAEYEDYLENGGEVLNWDDL

Download         Length: 216 bp

>AT27106 NC_017595:c1429811-1429596 [Streptococcus salivarius JIM8777]
ATGACAACAATTACATTGAAGGTTTCAGAGGCAGATAAGAAGTTCATGCAGGCCATTGCGAAATTTGAAGGGGTATCCTT
GTCAGAATTAATTCGTACCAAAACTTTAGAAGCCATTGAGGATGAATATGACGCTAGAGTAGCCGATTTGGCTTTGGCAG
AATATGAAGACTATCTTGAAAATGGTGGGGAGGTGCTAAATTGGGATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F8LI54

Antitoxin

Source ID Structure
AlphaFold DB F8HC66

References