Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3690117..3690467 Replicon chromosome
Accession NZ_CP117386
Organism Salmonella enterica subsp. enterica serovar Uganda strain RM011

Toxin (Protein)


Gene name IasE Uniprot ID A0A3X9ZUV0
Locus tag PQP90_RS18280 Protein ID WP_000994229.1
Coordinates 3690210..3690467 (+) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3690117..3690385 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP90_RS18250 3685229..3685606 - 378 WP_000739707.1 Imm8 family immunity protein -
PQP90_RS18255 3686339..3686704 - 366 WP_001231281.1 hypothetical protein -
PQP90_RS18260 3686670..3688016 - 1347 Protein_3572 RHS repeat-associated core domain-containing protein -
PQP90_RS18265 3688078..3688335 + 258 WP_000994229.1 SymE family type I addiction module toxin -
PQP90_RS18270 3688399..3688737 - 339 WP_000382983.1 hypothetical protein -
PQP90_RS18275 3689108..3690148 - 1041 Protein_3575 RHS repeat-associated core domain-containing protein -
- 3690117..3690385 - 269 - - Antitoxin
PQP90_RS18280 3690210..3690467 + 258 WP_000994229.1 SymE family type I addiction module toxin Toxin
PQP90_RS18285 3690531..3690869 - 339 WP_000382983.1 hypothetical protein -
PQP90_RS18290 3691240..3692997 - 1758 Protein_3578 RHS repeat domain-containing protein -
PQP90_RS18295 3693202..3693435 + 234 WP_000035941.1 hypothetical protein -
PQP90_RS18300 3693507..3693854 - 348 WP_000887296.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3664537..3693878 29341


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(14-56)


Sequences


Toxin        


Download         Length: 86 a.a.        Molecular weight: 9538.91 Da        Isoelectric Point: 7.2759

>T271029 WP_000994229.1 NZ_CP117386:3690210-3690467 [Salmonella enterica subsp. enterica serovar Uganda]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFETGRGVTVKISQGCIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Download         Length: 258 bp


Antitoxin


Download         Length: 269 bp

>AT271029 NZ_CP117386:c3690385-3690117 [Salmonella enterica subsp. enterica serovar Uganda]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTCACGCCGCGCCCGGTCTCAAATCCCGCTTCTTCCAGCCA
GTCACCCTTAAGGTGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGAGCGCGACAGCCTGCACCG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A3X9ZUV0


Antitoxin

Download structure file

References