Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4644361..4644963 Replicon chromosome
Accession NZ_CP117378
Organism Salmonella enterica subsp. enterica serovar Newport strain RM038

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag PQP81_RS22695 Protein ID WP_001159630.1
Coordinates 4644652..4644963 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PQP81_RS22690 Protein ID WP_000362050.1
Coordinates 4644361..4644651 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP81_RS22675 (4641854) 4641854..4642756 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
PQP81_RS22680 (4642753) 4642753..4643388 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
PQP81_RS22685 (4643385) 4643385..4644314 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
PQP81_RS22690 (4644361) 4644361..4644651 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
PQP81_RS22695 (4644652) 4644652..4644963 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
PQP81_RS22700 (4645181) 4645181..4646110 + 930 WP_001127704.1 alpha/beta hydrolase -
PQP81_RS22705 (4646196) 4646196..4646507 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
PQP81_RS22710 (4646504) 4646504..4646950 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
PQP81_RS22715 (4646965) 4646965..4647906 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
PQP81_RS22720 (4647951) 4647951..4648388 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
PQP81_RS22725 (4648385) 4648385..4649257 - 873 WP_000921423.1 virulence factor BrkB family protein -
PQP81_RS22730 (4649251) 4649251..4649850 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T270952 WP_001159630.1 NZ_CP117378:c4644963-4644652 [Salmonella enterica subsp. enterica serovar Newport]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT270952 WP_000362050.1 NZ_CP117378:c4644651-4644361 [Salmonella enterica subsp. enterica serovar Newport]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References