Detailed information of TA system TA270948

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3677437..3677869
• Replicon: chromosome
• Accession: NZ_CP117378
• Organism: Salmonella enterica subsp. enterica serovar Newport strain RM038

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A0R9NU89
• Locus tag: PQP81_RS18140
• Protein ID: WP_000994228.1
• Coordinates: 3677594..3677869 (+)
• Length: 92 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3677437..3677859 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PQP81_RS18110	3672663..3673157	-	495	WP_000800125.1	hypothetical protein	-
PQP81_RS18115	3673958..3674659	-	702	Protein_3544	integrase core domain-containing protein	-
PQP81_RS18120	3674712..3674960	+	249	WP_023165496.1	SymE family type I addiction module toxin	-
PQP81_RS18125	3675092..3675370	-	279	WP_020924058.1	hypothetical protein	-
PQP81_RS18130	3675687..3676154	-	468	WP_000828173.1	sugar tyrosine-protein kinase	-
PQP81_RS18135	3677027..3677260	-	234	WP_124084119.1	hypothetical protein	-
-	3677437..3677859	-	423	-	-	Antitoxin
PQP81_RS18140	3677594..3677869	+	276	WP_000994228.1	SymE family type I addiction module toxin	Toxin
PQP81_RS18145	3677922..3678404	-	483	WP_001286803.1	immunity 26/phosphotriesterase HocA family protein	-
PQP81_RS18150	3678923..3679369	-	447	WP_000935097.1	protein SciX	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3664142..3701201	37059
	-	flank	IS/Tn	-	-	3673958..3674236	278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10136.51 Da
• Isoelectric Point: 7.3224

>T270948 WP_000994228.1 NZ_CP117378:3677594-3677869 [Salmonella enterica subsp. enterica serovar Newport]
MNASGVSVRHINSETCMTTSYSHIPSQHLKGDWQEEAGFETGRSVTVKISKGCLILMAETDEVRELRKELYQVKKSMKHI
KAGVNDVVNGD

Nucleotide

• Length: 276 bp

Antitoxin

Nucleotide

• Length: 423 bp

>AT270948 NZ_CP117378:c3677859-3677437 [Salmonella enterica subsp. enterica serovar Newport]
TTCACCACATCATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGCTCCCTCAC
TTCGTCCGTCTCAGCCATCAGGATCAAACATCCCTTGGAGATCTTCACGGTCACGCTGCGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGTACCGGGCGGTGATGAACA
ACCGGCTACCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A0R9NU89

Antitoxin