Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3486118..3486738 Replicon chromosome
Accession NZ_CP117378
Organism Salmonella enterica subsp. enterica serovar Newport strain RM038

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PQP81_RS17235 Protein ID WP_001280991.1
Coordinates 3486520..3486738 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PQP81_RS17230 Protein ID WP_000344807.1
Coordinates 3486118..3486492 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP81_RS17220 (3481258) 3481258..3482451 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PQP81_RS17225 (3482474) 3482474..3485622 + 3149 Protein_3368 efflux RND transporter permease AcrB -
PQP81_RS17230 (3486118) 3486118..3486492 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PQP81_RS17235 (3486520) 3486520..3486738 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PQP81_RS17240 (3486917) 3486917..3487468 + 552 WP_001278792.1 maltose O-acetyltransferase -
PQP81_RS17245 (3487585) 3487585..3488055 + 471 WP_000136181.1 YlaC family protein -
PQP81_RS17250 (3488111) 3488111..3488251 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PQP81_RS17255 (3488257) 3488257..3488517 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PQP81_RS17260 (3488742) 3488742..3490292 + 1551 WP_000213138.1 EAL domain-containing protein -
PQP81_RS17270 (3490523) 3490523..3490912 + 390 WP_000961287.1 MGMT family protein -
PQP81_RS17275 (3490945) 3490945..3491514 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T270947 WP_001280991.1 NZ_CP117378:3486520-3486738 [Salmonella enterica subsp. enterica serovar Newport]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT270947 WP_000344807.1 NZ_CP117378:3486118-3486492 [Salmonella enterica subsp. enterica serovar Newport]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References