Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4771834..4772436 Replicon chromosome
Accession NZ_CP117367
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM079

Toxin (Protein)


Gene name higB Uniprot ID M7S4R6
Locus tag PQQ12_RS23365 Protein ID WP_001159635.1
Coordinates 4772125..4772436 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PQQ12_RS23360 Protein ID WP_000362050.1
Coordinates 4771834..4772124 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ12_RS23345 (4769327) 4769327..4770229 + 903 WP_000331367.1 formate dehydrogenase subunit beta -
PQQ12_RS23350 (4770226) 4770226..4770861 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
PQQ12_RS23355 (4770858) 4770858..4771787 + 930 WP_000027737.1 formate dehydrogenase accessory protein FdhE -
PQQ12_RS23360 (4771834) 4771834..4772124 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
PQQ12_RS23365 (4772125) 4772125..4772436 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
PQQ12_RS23370 (4772654) 4772654..4773583 + 930 WP_001127708.1 alpha/beta hydrolase -
PQQ12_RS23375 (4773669) 4773669..4773980 + 312 WP_000558169.1 type II toxin-antitoxin system HigB family toxin -
PQQ12_RS23380 (4773977) 4773977..4774423 + 447 WP_001259012.1 type II toxin-antitoxin system HigA family antitoxin -
PQQ12_RS23385 (4774438) 4774438..4775379 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
PQQ12_RS23390 (4775424) 4775424..4775861 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
PQQ12_RS23395 (4775858) 4775858..4776730 - 873 WP_000921423.1 virulence factor BrkB family protein -
PQQ12_RS23400 (4776724) 4776724..4777323 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12340.30 Da        Isoelectric Point: 9.4460

>T270861 WP_001159635.1 NZ_CP117367:c4772436-4772125 [Salmonella enterica subsp. enterica serovar Dublin]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT270861 WP_000362050.1 NZ_CP117367:c4772124-4771834 [Salmonella enterica subsp. enterica serovar Dublin]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JK97

Antitoxin

Source ID Structure

References