Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4355861..4356377 Replicon chromosome
Accession NZ_CP117367
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM079

Toxin (Protein)


Gene name relE Uniprot ID M7RIY5
Locus tag PQQ12_RS21450 Protein ID WP_000220574.1
Coordinates 4355861..4356145 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag PQQ12_RS21455 Protein ID WP_000212724.1
Coordinates 4356135..4356377 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ12_RS21435 (4350977) 4350977..4352629 + 1653 WP_001751520.1 alpha,alpha-phosphotrehalase -
PQQ12_RS21440 (4353038) 4353038..4355176 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
PQQ12_RS21445 (4355393) 4355393..4355857 + 465 WP_001009173.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PQQ12_RS21450 (4355861) 4355861..4356145 - 285 WP_000220574.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQQ12_RS21455 (4356135) 4356135..4356377 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PQQ12_RS21460 (4356455) 4356455..4358368 - 1914 WP_001212138.1 PRD domain-containing protein -
PQQ12_RS21465 (4358385) 4358385..4359125 - 741 WP_000779259.1 KDGP aldolase family protein -
PQQ12_RS21470 (4359122) 4359122..4360240 - 1119 WP_001139169.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
PQQ12_RS21475 (4360224) 4360224..4361357 - 1134 WP_000459958.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10869.68 Da        Isoelectric Point: 9.8739

>T270859 WP_000220574.1 NZ_CP117367:c4356145-4355861 [Salmonella enterica subsp. enterica serovar Dublin]
MTYELEFDPRALKEWHKLGDTVKAQIKKKLADVLLDPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT270859 WP_000212724.1 NZ_CP117367:c4356377-4356135 [Salmonella enterica subsp. enterica serovar Dublin]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M7RIY5

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References