Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3664462..3665082 Replicon chromosome
Accession NZ_CP117367
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM079

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PQQ12_RS18235 Protein ID WP_001280991.1
Coordinates 3664864..3665082 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PQQ12_RS18230 Protein ID WP_000344807.1
Coordinates 3664462..3664836 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ12_RS18220 (3659601) 3659601..3660794 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PQQ12_RS18225 (3660817) 3660817..3663966 + 3150 WP_052897443.1 efflux RND transporter permease AcrB -
PQQ12_RS18230 (3664462) 3664462..3664836 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PQQ12_RS18235 (3664864) 3664864..3665082 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PQQ12_RS18240 (3665261) 3665261..3665812 + 552 WP_001278787.1 maltose O-acetyltransferase -
PQQ12_RS18245 (3665930) 3665930..3666400 + 471 WP_000136183.1 YlaC family protein -
PQQ12_RS18250 (3666456) 3666456..3666596 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PQQ12_RS18255 (3666602) 3666602..3666862 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PQQ12_RS18260 (3667087) 3667087..3668637 + 1551 WP_000213140.1 EAL domain-containing protein -
PQQ12_RS18270 (3668868) 3668868..3669257 + 390 WP_000961287.1 MGMT family protein -
PQQ12_RS18275 (3669290) 3669290..3669859 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T270854 WP_001280991.1 NZ_CP117367:3664864-3665082 [Salmonella enterica subsp. enterica serovar Dublin]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT270854 WP_000344807.1 NZ_CP117367:3664462-3664836 [Salmonella enterica subsp. enterica serovar Dublin]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References