Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 2908138..2908676 Replicon chromosome
Accession NZ_CP117367
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM079

Toxin (Protein)


Gene name yafQ Uniprot ID M7RHM1
Locus tag PQQ12_RS14425 Protein ID WP_001526148.1
Coordinates 2908138..2908413 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID M7RMV7
Locus tag PQQ12_RS14430 Protein ID WP_000729713.1
Coordinates 2908416..2908676 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ12_RS14420 (2905345) 2905345..2908050 + 2706 WP_000907030.1 HTH-type transcriptional regulator MalT -
PQQ12_RS14425 (2908138) 2908138..2908413 - 276 WP_001526148.1 type II toxin-antitoxin system YafQ family toxin Toxin
PQQ12_RS14430 (2908416) 2908416..2908676 - 261 WP_000729713.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PQQ12_RS14435 (2908785) 2908785..2909796 - 1012 Protein_2826 RNA 3'-terminal phosphate cyclase -
PQQ12_RS14440 (2909800) 2909800..2911014 - 1215 WP_052895987.1 RNA-splicing ligase RtcB -
PQQ12_RS14445 (2911362) 2911362..2912915 - 1554 WP_000013013.1 TROVE domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2908138..2917754 9616


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10739.34 Da        Isoelectric Point: 8.8652

>T270853 WP_001526148.1 NZ_CP117367:c2908413-2908138 [Salmonella enterica subsp. enterica serovar Dublin]
MGQREIEYSGQFQKDVKRAQKRHKDVGKLKTLMTLLIHHPFPLPAIYKDHPLQGSYSGYRDAHIEPDWILIYKITDECLR
FERTGTHADLF

Download         Length: 276 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9446.80 Da        Isoelectric Point: 4.4734

>AT270853 WP_000729713.1 NZ_CP117367:c2908676-2908416 [Salmonella enterica subsp. enterica serovar Dublin]
MAANALVRARIDETLKDQAADVLAEMGLTISDLIRITLTKVAREKALPFDLRIPNELTSRTIENSEAGVDIHKAKDADDL
FDQLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V4SM83

Antitoxin

Source ID Structure
AlphaFold DB A0A4D6P2L2

References